Sent from my iPad Begin forwarded message:

From: PNAS Date: September 24, 2024 at 1:16:33 PM GMT-3 To: mhallak@fcq.unc.edu.ar Subject: Proceedings of the National Academy of Sciences Vol. 121, No. 39, September 24, 2024 is now available online Reply-To: no-reply@pnas.nas.edu

New Issue Available

SEPTEMBER 24, 2024 | VOL.121 | NO.39 VIEW TABLE OF CONTENTS Lasker Awards 2024

The boogie-woogie approach to creativity in art and science Joseph L. Goldstein Hunting down the elusive cytosolic-DNA sensor Diane Mathis The discovery and development of GLP-1 based drugs that have revolutionized the treatment of obesity Jeffrey M. Friedman QnAs with Zhijian “James” Chen: Winner of the 2024 Albert Lasker Basic Medical Research Award Matthew Hardcastle QnAs with Svetlana Mojsov, Joel Habener, and Lotte Bjerre Knudsen: Winners of the 2024 Lasker~DeBakey Clinical Medical Research Award Prashant Nair QnAs with Quarraisha Abdool Karim and Salim Abdool Karim: Winners of the 2024 Lasker~Bloomberg Public Service Award Tinsley H. Davis This Week in PNAS

In This Issue Opinion

On the anniversary of the Maui fires, a call for Indigenous land care to mitigate future disasters D. Nākoa Farrant, Clay Trauernicht, Aurora Kagawa-Viviani, Thomas W. Giambelluca and Carla M. D'Antonio Retrospective

Maxine Singer: A laser-sharp intellect with a passion for science Susanne Garvey Profile

Profile of Mario Luis Small Jill Langlois Commentaries

The primary cilium of cholinergic neurons may be a linchpin in the progression of Parkinson’s Disease Santiago Uribe-Cano and Andreas H. Kottmann Advantage of an epigenetic switch in response to alternate environments David Low Do Black doctors save more Black babies? Theodore Joyce Perspective

N-degron pathways Alexander Varshavsky Letters

Calibrating the genomic clock of modern birds using fossils Santiago Claramunt, Edward L. Braun, Joel Cracraft, Jon Fjeldså, Simon Y. W. Ho, Peter Houde, Jacqueline M. T. Nguyen and Josefin Stiller Reply to Claramunt et al.: Robustness of the Cretaceous radiation of crown aves Shaoyuan Wu, Frank E. Rheindt, Jin Zhang, Jiajia Wang, Lei Zhang, Cheng Quan, Zhiheng Li, Min Wang, Feixiang Wu, Yanhua Qu, Scott V. Edwards, Zhonghe Zhou and Liang Liu Early characterization of excitation–contraction coupling and SLO-2 channel properties in Caenorhabditis elegans muscle cells Bruno Allard Response to Allard: A minor (albeit significant) role for voltage-induced calcium release in Caenorhabditis elegans muscles Luna Gao, Evan Ardiel, Stephen Nurrish and Joshua M. Kaplan Contradiction: Inhibiting inflammation and immunosuppression in the treatment of IBD Wenfu Cao, Yongjian Xiong and Dapeng Chen Brief Reports

Agricultural flood resistance enhanced after returning farmlands to lakes Ruoqi Liu, Jinwei Dong, Luguang Jiang, Yong Ge, Chang Fan, Tong Yang and Geli Zhang Utilizing big data without domain knowledge impacts public health decision-making Miao Zhang, Salman Rahman, Vishwali Mhasawade and Rumi Chunara Physical Sciences

Applied Physical Sciences Spontaneous assembly of condensate networks during the demixing of structured fluids Yuma Morimitsu, Christopher A. Browne, Zhe Liu, Paul G. Severino, Manesh Gopinadhan, Eric B. Sirota, Ozcan Altintas, Kazem V. Edmond and Chinedum O. Osuji Atomic-engineered gradient tunable solid-state metamaterials Zhiyuan Yan, Albertus Denny Handoko, Weikang Wu, Chuchu Yang, Hao Wang, Meltem Yilmaz, Zhiyong Zhang, Libo Cheng, Xinbin Cheng, Ghim Wei Ho, Bin Feng, Naoya Shibata, Rong Zhao, Joel K. W. Yang, Chong Tow Chong, Yuichi Ikuhara and Cheng-Wei Qiu Nanoscale dynamics of the cadherin–catenin complex bound to vinculin revealed by neutron spin echo spectroscopy David J. E. Callaway, Iain D. Nicholl, Bright Shi, Gilbert Reyes, Bela Farago and Zimei Bu Astronomy Refractive lensing of scintillating FRBs by subparsec cloudlets in the multiphase CGM Dylan L. Jow, Xiaohan Wu and Ue-Li Pen Biophysics and Computational Biology Differential roles of kinetic on- and off-rates in T-cell receptor signal integration revealed with a modified Fab’-DNA ligand Kiera B. Wilhelm, Anand Vissa and Jay T. Groves Physical extraction of antigen and information Hongda Jiang and Shenshen Wang Chemistry Generating interstitial water within the persisting tetrahedral H-bond network explains density increase upon compressing liquid water Mirko Förster, Nnanna Ukoji, Christoph J. Sahle, Johannes Niskanen, Robin Sakrowski, Göran Surmeier, Christopher Weis, Tetsuo Irifune, Sho Imoto, Hasan Yavas, Simo Huotari, Dominik Marx, Christian Sternemann and John S. Tse Phosphorescent metallaknots of Au(I)-bis(acetylide) strands directed by Cu(I) π-coordination Ya-Zi Huang, Raorao Yang, Liang Zhang and Zhong-Ning Chen Earth, Atmospheric, and Planetary Sciences Estimating future climate change impacts on human mortality and crop yields via air pollution Lee T. Murray, Eric M. Leibensperger, Loretta J. Mickley and Amos P. K. Tai Zircon geochemistry from early evolved terranes records coeval stagnant- and mobile-lid tectonic regimes Emily E. Mixon, Ann M. Bauer, Tyler B. Blum, John W. Valley, Hanika Rizo, Jonathan O’Neil and Kouki Kitajima Impacts of Atlantic meridional overturning circulation weakening on Arctic amplification Yu-Chi Lee, Wei Liu, Alexey V. Fedorov, Nicole Feldl and Patrick C. Taylor Arctic halogens reduce ozone in the northern mid-latitudes Rafael P. Fernandez, Lucas Berná, Orlando G. Tomazzeli, Anoop S. Mahajan, Qinyi Li, Douglas E. Kinnison, Siyuan Wang, Jean-François Lamarque, Simone Tilmes, Henrik Skov, Carlos A. Cuevas and Alfonso Saiz-Lopez Engineering Measurement of adhesion and traction of cells at high yield reveals an energetic ratchet operating during nephron condensation Jiageng Liu, Louis S. Prahl, Aria Zheyuan Huang and Alex J. Hughes A machine learning–based framework for mapping hydrogen at the atomic scale Qingkun Zhao, Qi Zhu, Zhenghao Zhang, Binglun Yin, Huajian Gao and Haofei Zhou Genetic variation drives cancer cell adaptation to ECM stiffness Ting-Ching Wang, Suchitaa Sawhney, Daylin Morgan, Richard L. Bennett, Richa Rashmi, Marcos R. Estecio, Amy Brock, Irtisha Singh, Charles F. Baer, Jonathan D. Licht and Tanmay P. Lele Microbial community interactions on a chip Duane S. Juang, Wren E. Wightman, Gabriel L. Lozano, Terry D. Juang, Layla J. Barkal, Jiaquan Yu, Manuel F. Garavito, Amanda Hurley, Ophelia S. Venturelli, Jo Handelsman and David J. Beebe Mathematics Integer partitions detect the primes William Craig, Jan-Willem van Ittersum and Ken Ono Physics Generating interstitial water within the persisting tetrahedral H-bond network explains density increase upon compressing liquid water Mirko Förster, Nnanna Ukoji, Christoph J. Sahle, Johannes Niskanen, Robin Sakrowski, Göran Surmeier, Christopher Weis, Tetsuo Irifune, Sho Imoto, Hasan Yavas, Simo Huotari, Dominik Marx, Christian Sternemann and John S. Tse Meandering conduction channels and the tunable nature of quantized charge transport Benoit Douçot, Dmitry Kovrizhin and Roderich Moessner Unraveling the origin of Kondo-like behavior in the 3d-electron heavy-fermion compound YFe2Ge2 Bing Xu, Rui Liu, Hongliang Wo, Zhiyu Liao, Shaohui Yi, Chunhong Li, Jun Zhao, Xianggang Qiu, Zhiping Yin and Christian Bernhard Statistics Beyond Neyman–Pearson: E-values enable hypothesis testing with a data-driven alpha Peter D. Grünwald Social Sciences

Demography Physician–patient racial concordance and newborn mortality George J. Borjas and Robert VerBruggen Economic Sciences Augmenting the availability of historical GDP per capita estimates through machine learning Philipp Koch, Viktor Stojkoski and César A. Hidalgo Inequality aversion predicts support for public and private redistribution Thomas F. Epper, Ernst Fehr, Claus Thustrup Kreiner, Søren Leth-Petersen, Isabel Skak Olufsen and Peer Ebbesen Skov Political Sciences Illusory interparty disagreement: Partisans agree on what hate speech to censor but do not know it Brittany C. Solomon, Matthew E. K. Hall, Abigail Hemmen and James N. Druckman Psychological and Cognitive Sciences Language sentiment predicts changes in depressive symptoms Jihyun K. Hur, Joseph Heffner, Gloria W. Feng, Jutta Joormann and Robb B. Rutledge Sustainability Science Estimating future climate change impacts on human mortality and crop yields via air pollution Lee T. Murray, Eric M. Leibensperger, Loretta J. Mickley and Amos P. K. Tai Biological Sciences

Agricultural Sciences Heritable gene editing in tomato through viral delivery of isopentenyl transferase and single-guide RNAs to latent axillary meristematic cells Degao Liu, Evan E. Ellison, Erik A. Myers, Lilee I. Donahue, Shuya Xuan, Ryan Swanson, Songyan Qi, Lynn E. Prichard, Colby G. Starker and Daniel F. Voytas Biochemistry Fructose-2,6-bisphosphate restores DNA repair activity of PNKP and ameliorates neurodegenerative symptoms in Huntington’s disease Anirban Chakraborty, Sravan Gopalkrishnashetty Sreenivasmurthy, Wyatt Miller, Weihan Huai, Tapan Biswas, Santi Mohan Mandal, Lisardo Boscá, Balaji Krishnan, Gourisankar Ghosh and Tapas Hazra Biophysics and Computational Biology Atomistic mechanisms of the regulation of small-conductance Ca2+-activated K+ channel (SK2) by PIP2 Ryan L. Woltz, Yang Zheng, Woori Choi, Khoa Ngo, Pauline Trinh, Lu Ren, Phung N. Thai, Brandon J. Harris, Yanxiao Han, Kyle C. Rouen, Diego Lopez Mateos, Zhong Jian, Ye Chen-Izu, Eamonn J. Dickson, Ebenezer N. Yamoah, Vladimir Yarov-Yarovoy, Igor Vorobyov, Xiao-Dong Zhang and Nipavan Chiamvimonvat A molten globule ensemble primes Arf1–GDP for the nucleotide switch Tejaswi Koduru, Noam Hantman, Edgar V. Peters, Michel W. Jaworek, Jinqiu Wang, Siwen Zhang, Scott A. McCallum, Richard E. Gillilan, Martin J. Fossat, Christian Roumestand, Amin Sagar, Roland Winter, Pau Bernadó, Jacqueline Cherfils and Catherine A. Royer Spatiotemporal formation of a single liquid-like condensate and amyloid fibrils of α-synuclein by optical trapping at solution surface Keisuke Yuzu, Ching-Yang Lin, Po-Wei Yi, Chih-Hao Huang, Hiroshi Masuhara and Eri Chatani Cell Biology Activation induces shift in nutrient utilization that differentially impacts cell functions in human neutrophils Emily C. Britt, Xin Qing, James A. Votava, Jorgo Lika, Andrew S. Wagner, Simone Shen, Nicholas L. Arp, Hamidullah Khan, Stefan M. Schieke, Christopher D. Fletcher, Anna Huttenlocher and Jing Fan The p53 target DRAM1 modulates calcium homeostasis and ER stress by promoting contact between lysosomes and the ER through STIM1 Xiying Wang, Ji Geng, Suman Rimal, Yuxiu Sui, Jie Pan, Zhenghong Qin and Bingwei Lu Hippo effector, Yorkie, is a tumor suppressor in select Drosophila squamous epithelia Rachita Bhattacharya, Jaya Kumari, Shweta Banerjee, Jyoti Tripathi, Saurabh Singh Parihar, Nitin Mohan and Pradip Sinha Actomyosin contraction in the follicular epithelium provides the major mechanical force for follicle rupture during Drosophila ovulation Stella E. Cho, Wei Li, Andrew M. Beard, Jonathan A. Jackson, Risa Kiernan, Kazunori Hoshino, Adam C. Martin and Jianjun Sun Developmental Biology Measurement of adhesion and traction of cells at high yield reveals an energetic ratchet operating during nephron condensation Jiageng Liu, Louis S. Prahl, Aria Zheyuan Huang and Alex J. Hughes Etiology of craniofacial and cardiac malformations in a mouse model of SF3B4-related syndromes Shruti Kumar, Eric Bareke, Jimmy Lee, Emma Carlson, Fjodor Merkuri, Evelyn E. Schwager, Steven Maglio, Jennifer L. Fish, Jacek Majewski and Loydie A. Jerome-Majewska Transdifferentiation occurs without resetting development-specific DNA methylation, a key determinant of full-function cell identity Ahmed Radwan, Jason Eccleston, Ofra Sabag, Howard Marcus, Jonathan Sussman, Alberto Ouro, Moran Rahamim, Meir Azagury, Batia Azria, Ben Z. Stanger, Howard Cedar and Yosef Buganim Ecology Enhanced effects of species richness on resistance and resilience of global tree growth to prolonged drought Yun-Hao Bai and Zhiyao Tang Evolution The battle of the sexes in humans is highly polygenic Jared M. Cole, Carly B. Scott, Mackenzie M. Johnson, Peter R. Golightly, Jedidiah Carlson, Matthew J. Ming, Arbel Harpak and Mark Kirkpatrick Increased incidences of cervical ribs in deer indicate extinction risk Raimon Cuxart-Erruz, Tom J. M. Van Dooren, Alexandra A. E. van der Geer and Frietson Galis Evolution of pH-sensitive transcription termination in Escherichia coli during adaptation to repeated long-term starvation Sarah B. Worthan, Robert D. P. McCarthy, Mildred Delaleau, Ryan Stikeleather, Benjamin P. Bratton, Marc Boudvillain and Megan G. Behringer Revisiting the four Hexapoda classes: Protura as the sister group to all other hexapods Shiyu Du, Erik Tihelka, Daoyuan Yu, Wan-Jun Chen, Yun Bu, Chenyang Cai, Michael S. Engel, Yun-Xia Luan and Feng Zhang Genome of Halimeda opuntia reveals differentiation of subgenomes and molecular bases of multinucleation and calcification in algae Hao Zhang, Xin Wang, Meng Qu, Haiyan Yu, Jianping Yin, Xiaochuan Liu, Yuhong Liu, Bo Zhang, Yanhong Zhang, Zhangliang Wei, Fangfang Yang, Jingtian Wang, Chengcheng Shi, Guangyi Fan, Jun Sun, Lijuan Long, David A. Hutchins, Chris Bowler, Senjie Lin, Dazhi Wang and Qiang Lin Genetics Nuclear dualism without extensive DNA elimination in the ciliate Loxodes magnus Brandon K. B. Seah, Aditi Singh, David E. Vetter, Christiane Emmerich, Moritz Peters, Volker Soltys, Bruno Huettel and Estienne C. Swart Immunology and Inflammation Differential roles of kinetic on- and off-rates in T-cell receptor signal integration revealed with a modified Fab’-DNA ligand Kiera B. Wilhelm, Anand Vissa and Jay T. Groves The telencephalon is a neuronal substrate for systemic inflammatory responses in teleosts via polyamine metabolism Amir Mani, Farah Haddad, Daniel R. Barreda and Irene Salinas Transcription factor EGR2 alleviates autoimmune uveitis via activation of GDF15 to modulate the retinal microglial phenotype Wanqian Li, Siyuan He, Jun Tan, Na Li, Chenyang Zhao, Xiaotang Wang, Zhi Zhang, Jiangyi Liu, Jiaxing Huang, Xingran Li, Qian Zhou, Ke Hu, Peizeng Yang and Shengping Hou SARS-CoV-2-specific CD8+ T cells from people with long COVID establish and maintain effector phenotype and key TCR signatures over 2 years Louise C. Rowntree, Jennifer Audsley, Lilith F. Allen, Hayley A. McQuilten, Ruth R. Hagen, Priyanka Chaurasia, Jan Petersen, Dene R. Littler, Hyon-Xhi Tan, Lydia Murdiyarso, Jennifer R. Habel, Isabelle J. H. Foo, Wuji Zhang, Elizabeth R. V. ten Berge, Hanujah Ganesh, Prathanporn Kaewpreedee, Kelly W. K. Lee, Samuel M. S. Cheng, Janette S. Y. Kwok, Dhilshan Jayasinghe, Stephanie Gras, Jennifer A. Juno, Adam K. Wheatley, Stephen J. Kent, Jamie Rossjohn, Allen C. Cheng, Tom C. Kotsimbos, Jason A. Trubiano, Natasha E. Holmes, Ken Ka Pang Chan, David S. C. Hui, Malik Peiris, Leo L. M. Poon, Sharon R. Lewin, Peter C. Doherty, Irani Thevarajan, Sophie A. Valkenburg, Katherine Kedzierska and Thi H. O. Nguyen Medical Sciences On the development and validation of large language model-based classifiers for identifying social determinants of health Rodney A. Gabriel, Onkar Litake, Sierra Simpson, Brittany N. Burton, Ruth S. Waterman and Alvaro A. Macias Agonist antibody to MuSK protects mice from MuSK myasthenia gravis Julien Oury, Begona Gamallo-Lana, Leah Santana, Christophe Steyaert, Dana L. E. Vergoossen, Adam C. Mar, Bernhardt Vankerckhoven, Karen Silence, Roeland Vanhauwaert, Maartje G. Huijbers and Steven J. Burden The androgen receptor in mesenchymal progenitors regulates skeletal muscle mass via Igf1 expression in male mice Hiroshi Sakai, Hideaki Uno, Harumi Yamakawa, Kaori Tanaka, Aoi Ikedo, Akiyoshi Uezumi, Yasuyuki Ohkawa and Yuuki Imai In vivo CRISPR screens identify Mga as an immunotherapy target in triple-negative breast cancer Xu Feng, Chang Yang, Yuanjian Huang, Dan Su, Chao Wang, Lori Lyn Wilson, Ling Yin, Mengfan Tang, Siting Li, Zhen Chen, Dandan Zhu, Shimin Wang, Shengzhe Zhang, Jie Zhang, Huimin Zhang, Litong Nie, Min Huang, Jae-Il Park, Traver Hart, Dadi Jiang, Kuirong Jiang and Junjie Chen Microbiology Microbial community interactions on a chip Duane S. Juang, Wren E. Wightman, Gabriel L. Lozano, Terry D. Juang, Layla J. Barkal, Jiaquan Yu, Manuel F. Garavito, Amanda Hurley, Ophelia S. Venturelli, Jo Handelsman and David J. Beebe The surface interface and swimming motility influence surface-sensing responses in Pseudomonas aeruginosa Xuhui Zheng, Emma J. Gomez-Rivas, Sabrina I. Lamont, Katayoun Daneshjoo, Angeli Shieh, Daniel J. Wozniak and Matthew R. Parsek Conformational ensembles in Klebsiella pneumoniae FimH impact uropathogenesis Edward D. B. Lopatto, Jerome S. Pinkner, Denise A. Sanick, Robert F. Potter, Lily X. Liu, Jesús Bazán Villicaña, Kevin O. Tamadonfar, Yijun Ye, Maxwell I. Zimmerman, Nathaniel C. Gualberto, Karen W. Dodson, James W. Janetka, David A. Hunstad and Scott J. Hultgren Manipulation of natural transformation by AbaR-type islands promotes fixation of antibiotic resistance in Acinetobacter baumannii Rémi Tuffet, Gabriel Carvalho, Anne-Sophie Godeux, Fanny Mazzamurro, Eduardo P. C. Rocha, Maria-Halima Laaberki, Samuel Venner and Xavier Charpentier The Pentamer glycoprotein complex inhibits viral Immediate Early transcription during Human Cytomegalovirus infections Michael S. Ohman, Emily R. Albright, Christopher B. Gelbmann and Robert F. Kalejta Neuroscience Glial swip-10 controls systemic mitochondrial function, oxidative stress, and neuronal viability via copper ion homeostasis Peter Rodriguez, Vrinda Kalia, Cristina Fenollar-Ferrer, Chelsea L. Gibson, Zayna Gichi, Andre Rajoo, Carson D. Matier, Aidan T. Pezacki, Tong Xiao, Lucia Carvelli, Christopher J. Chang, Gary W. Miller, Andy V. Khamoui, Jana Boerner and Randy D. Blakely Lipin1 depletion coordinates neuronal signaling pathways to promote motor and sensory axon regeneration after spinal cord injury Weitao Chen, Junqiang Wu, Chao Yang, Suying Li, Zhewei Liu, Yongyan An, Xuejie Wang, Jiaming Cao, Jiahui Xu, Yangyang Duan, Xue Yuan, Xin Zhang, Yiren Zhou, Jacque Pak Kan Ip, Amy K. Y. Fu, Nancy Y. Ip, Zhongping Yao and Kai Liu Olfactory deficit and gastrointestinal dysfunction precede motor abnormalities in alpha-Synuclein G51D knock-in mice YoungDoo Kim, Joseph McInnes, Jiyoen Kim, Yan Hong Wei Liang, Surabi Veeraragavan, Alexandra Rae Garza, Benjamin David Webst Belfort, Benjamin Arenkiel, Rodney Samaco and Huda Yahya Zoghbi Neural network architecture of a mammalian brain Larry W. Swanson, Joel D. Hahn and Olaf Sporns Plant Biology Mesophyll airspace unsaturation drives C4 plant success under vapor pressure deficit stress Diego A. Márquez, Suan Chin Wong, Hilary Stuart-Williams, Lucas A. Cernusak and Graham D. Farquhar Population Biology Unraveling the genomic diversity and admixture history of captive tigers in the United States Ellie E. Armstrong, Jazlyn A. Mooney, Katherine A. Solari, Bernard Y. Kim, Gregory S. Barsh, Victoria B. Grant, Gili Greenbaum, Christopher B. Kaelin, Katya Panchenko, Joseph K. Pickrell, Noah Rosenberg, Oliver A. Ryder, Tsuya Yokoyama, Uma Ramakrishnan, Dmitri A. Petrov and Elizabeth A. Hadly Psychological and Cognitive Sciences Humans flexibly integrate social information despite interindividual differences in reward Alexandra Witt, Wataru Toyokawa, Kevin N. Lala, Wolfgang Gaissmaier and Charley M. Wu Correction

Correction for Lu et al., In situ electrogenerated Cu(III) triggers hydroxyl radical production on the Cu-Sb-SnO2 electrode for highly efficient water decontamination SI Correction

Correction to Supporting Information for Woerman et al., Familial Parkinson’s point mutation abolishes multiple system atrophy prion replication

To update which email alerts you receive, manage your alerts within the My Account area.

You can also unsubscribe from this alert with one click.

If you need any further help, please contact us at pnas@nas.edu