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From: PNAS <no-reply@pnas.nas.edu> Date: January 7, 2025 at 2:29:26 PM GMT-3 To: mhallak@fcq.unc.edu.ar Subject: Proceedings of the National Academy of Sciences Vol. 122, No. 1, January 7, 2025 is now available online Reply-To: no-reply@pnas.nas.edu

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JANUARY 7, 2025 | VOL.122 | NO.1 VIEW TABLE OF CONTENTS

This Week in PNAS

In This Issue Opinion

Zoos must embrace animal death for education and conservation Marcus Clauss, Marco Roller, Mads Frost Bertelsen, Claudia Rudolf von Rohr, Dennis W. H. Müller, Christian Schiffmann, Maya Kummrow, Dag Encke, Sam Ferreira, Ethan S. Duvall, Celesté Maré and Andrew J. Abraham Profile

Profile of Stefan W. Hell Sandeep Ravindran Commentaries

Quantifying the genetic origins of body plan scaling Vahe Galstyan and Pieter Rein ten Wolde Deciphering the artificial evolution of domesticated plants within dynamic habitats David L. Lentz and Mary E. D. Pohl Multitude of glasses of water Francesco Sciortino Electrochemical NAD+ regeneration in bacterial organelles Carolyn E. Mills Development of precision medicine approaches to advance clinical trials for autism and social behavior: A research imperative Kelsie A. Boulton and Adam J. Guastella Perspective

How and why funders support engaged research Angela T. Bednarek, Ben Miyamoto, Kristin Corbett, Charlotte Hudson, Gayle Scarrow, Maeghan Brass, Kim DuMont, Bev Holmes, Lauren Supplee, Robert McLean, Jaspal Bhatia, Shamira Chappell, Maggie Gorman Vélez and Chhaya Kolavalli Letters

The unexplored potential of exosomes in the muscle–brain axis Celeste Caruso Bavisotto, Fabio Bucchieri and Francesco Cappello Reply to Caruso Bavisotto et al.: Toward exploring the potential of muscle-secreting exosomes in the muscle–brain axis Kai-Yu Huang, Hee Jung Chung and Hyunjoon Kong Parallel vector memories or single memory updating? Fengxiang Zhang, Yi Pu and Xiang-Zhen Kong Reply to Zhang et al.: Parallel vector memories are required to explain all behavioral data in navigating bumblebees Rickesh N. Patel, Natalie S. Roberts, Julian Kempenaers, Ana Zadel and Stanley Heinze Brief Reports

Across the firewall: Foreign media’s role in shaping Chinese social media narratives on the Russo-Ukrainian War Hans W. A. Hanley, Yingdan Lu and Jennifer Pan Integration of basal and apical embryo lineage regulators controls F-actin cable integrity and zygote asymmetry in Arabidopsis Feng Xiong, Zhongjuan Zhang, Wen Gong, Marita Hermann, Deniz Tiambeng Bak, Frauke Garbsch and Thomas Laux Physical Sciences

Applied Physical Sciences Confined cell migration along extracellular matrix space in vivo Oleksandr Chepizhko, Josep-Maria Armengol-Collado, Stephanie Alexander, Esther Wagena, Bettina Weigelin, Luca Giomi, Peter Friedl, Stefano Zapperi and Caterina A. M. La Porta Nucleation mechanism of multiple-order parameter ferroelectric domain wall motion in hafnia Songsong Zhou and Andrew M. Rappe Geometrically modulated contact forces enable hula hoop levitation Xintong Zhu, Olivia Pomerenk and Leif Ristroph Moiré magnetism and moiré excitons in twisted CrSBr bilayers Junyi Liu, Xu Zhang and Gang Lu Biophysics and Computational Biology Modular DNA origami–based electrochemical detection of DNA and proteins Byoung-jin Jeon, Matteo M. Guareschi, Jaimie Marie Stewart, Emily Wu, Ashwin Gopinath, Netzahualcóyotl Arroyo-Currás, Philippe Dauphin-Ducharme, Kevin W. Plaxco, Philip S. Lukeman and Paul W. K. Rothemund A minimal vertex model explains how the amnioserosa avoids fluidization during Drosophila dorsal closure Indrajit Tah, Daniel Haertter, Janice M. Crawford, Daniel P. Kiehart, Christoph F. Schmidt and Andrea J. Liu The carnivorous plant Genlisea harnesses active particle dynamics to prey on microfauna José Martín-Roca, C. Miguel Barriuso G., Raúl Martínez Fernández, Camila Betterelli Giuliano, Rongjing Zhang, Chantal Valeriani and Laurence G. Wilson Chromatin enables precise and scalable gene regulation with factors of limited specificity Mindy Liu Perkins, Justin Crocker and Gašper Tkačik Higher-order transient structures and the principle of dynamic connectivity in membrane signaling Yuxi Zhang and Roderick MacKinnon Higher-order transient membrane protein structures Yuxi Zhang, Hisham Mazal, Venkata Shiva Mandala, Gonzalo Pérez-Mitta, Vahid Sondoghdar, Christoph A. Haselwandter and Roderick MacKinnon Stochastic morphological swings in Hydra regeneration: A manifestation of noisy canalized morphogenesis Oded Agam and Erez Braun PhiSiCal-Checkup: A Bayesian framework to validate amino acid conformations within experimental protein structures Piyumi R. Amarasinghe, Lloyd Allison, Craig J. Morton, Peter J. Stuckey, Maria Garcia de la Banda, Arthur M. Lesk and Arun S. Konagurthu Chemistry Elucidation of a distinct photoreduction pathway in class II Arabidopsis thaliana photolyase Zhongneng Zhou, Zijing Chen, Xiu-Wen Kang, Bei Ding, Shuhua Zou, Siwei Tang, Yalin Zhou, Bingyao Wang and Dongping Zhong Unveiling hidden reaction kinetics of carbon dioxide in supercritical aqueous solutions Chu Li, Yuan Yao and Ding Pan An exchangeable SIM probe for monitoring organellar dynamics of necrosis cells and intracellular water heterogeneity in kidney repair Youbo Lai, Tengteng Zhang, Ling Huang, Andrey S. Klymchenko and Weiying Lin Liquid-nano-liquid interface–oriented anisotropic encapsulation Yating Zhan, Xirui Huang, Minchao Liu, Runfeng Lin, Hongyue Yu, Yufang Kou, Enyun Xing, Ahmed A. Elzatahry, Mohamed F. Mady, Dongyuan Zhao, Tiancong Zhao and Xiaomin Li A hybrid meta on-top functional for multiconfiguration pair-density functional theory Jie J. Bao, Dayou Zhang, Shaoting Zhang, Laura Gagliardi and Donald G. Truhlar Unlocking the catalytic precision of ligand-controlled enzymatic halogenation Aisaraphon Phintha, April L. Lukowski and Pimchai Chaiyen Trojan horse peptide conjugates remodel the activity spectrum of clinical antibiotics Shangwen Luo, Xin-Rong Li, Xiao-Tong Gong, Alexey Kulikovsky, Feng Qu, Konstantinos Beis, Konstantin Severinov, Svetlana Dubiley, Xinxin Feng, Shi-Hui Dong and Satish K. Nair Computer Sciences Image segmentation with traveling waves in an exactly solvable recurrent neural network Luisa H. B. Liboni, Roberto C. Budzinski, Alexandra N. Busch, Sindy Löwe, Thomas A. Keller, Max Welling and Lyle E. Muller A phase transition in diffusion models reveals the hierarchical nature of data Antonio Sclocchi, Alessandro Favero and Matthieu Wyart Earth, Atmospheric, and Planetary Sciences The effect of CO2 ramping rate on the transient weakening of the Atlantic Meridional Overturning Circulation Camille Hankel The 1831 CE mystery eruption identified as Zavaritskii caldera, Simushir Island (Kurils) William Hutchison, Patrick Sugden, Andrea Burke, Peter Abbott, Vera V. Ponomareva, Oleg Dirksen, Maxim V. Portnyagin, Breanyn MacInnes, Joanne Bourgeois, Ben Fitzhugh, Magali Verkerk, Thomas J. Aubry, Samantha L. Engwell, Anders Svensson, Nathan J. Chellman, Joseph R. McConnell, Siwan Davies, Michael Sigl and Gill Plunkett The return of stagnant slab recorded by intraplate volcanism Zhong-Biao Zhou, Li-Hui Chen, Zhou-Chuan Huang, Albrecht W. Hofmann, Xiao-Jun Wang, Gang Zeng, Ya-Jing Bi and Jian Zhao US Corn Belt enhances regional precipitation recycling Zhe Zhang, Cenlin He, Fei Chen, Gonzalo Miguez-Macho, Changhai Liu and Roy Rasmussen Metastable state preceding shear zone instability: Implications for earthquake-accelerated landslides and dynamic triggering Yan Li, Wei Hu, Qiang Xu, Hui Luo, Chingshung Chang and Xiaoping Jia Aerosol light absorption alleviates particulate pollution during wintertime haze events Jiarui Wu, Naifang Bei, Yuan Wang, Xiaoli Su, Ningning Zhang, Lili Wang, Bo Hu, Qiyuan Wang, Qian Jiang, Chenchong Zhang, Yangfan Liu, Ruonan Wang, Xia Li, Yuxuan Lu, Zirui Liu, Junji Cao, Xuexi Tie, Guohui Li and John Seinfeld Persistent humid climate favored the Qin and Western Han Dynasties in China around 2,200 y ago Chun Qin, Bao Yang, Achim Bräuning, Fredrik Charpentier Ljungqvist, Timothy J. Osborn, Vladimir Shishov, Minhui He, Shuyuan Kang, Lea Schneider, Jan Esper, Ulf Büntgen, Jussi Grießinger, Danqing Huang, Peng Zhang, Stefanie Talento, Elena Xoplaki, Jürg Luterbacher and Nils Chr. Stenseth Engineering Fast-chargeable lithium-ion batteries by μ-Si anode-tailored full-cell design Taeyong Lee, Min Ji Seong, Hyo Chul Ahn, Minsung Baek, Kiho Park, Jihoon Oh, Taehoon Choi and Jang Wook Choi Physics Nocturnal camouflage through background matching against moonlight Juan J. Negro, Salvador Bará, David Galadí-Enríquez, Juan Luis Nieves, Miguel A. Martínez-Domingo, Alejandro Ferrero, Joaquín Campos, Carmen Bao-Varela, Eduard Masana and Carlos Camacho Pseudogap in electron-doped cuprates: Strong correlation leading to band splitting Masafumi Horio, Shiro Sakai, Hakuto Suzuki, Yosuke Nonaka, Makoto Hashimoto, Donghui Lu, Zhi-Xun Shen, Taro Ohgi, Takuya Konno, Tadashi Adachi, Yoji Koike, Masatoshi Imada and Atsushi Fujimori Restart uncertainty relation for monitored quantum dynamics Ruoyu Yin, Qingyuan Wang, Sabine Tornow and Eli Barkai Time evolution of a pumped molecular magnet—A time-resolved inelastic neutron scattering study T. R. Reeder, Paraj Titum, J. Kindervater, V. J. Stewart, Q. Ye, J. A. Rodriguez-Rivera, Y. Qiu, N. Maliszewskyj, T. M. McQueen and C. L. Broholm Evidence for a metal–bosonic insulator–superconductor transition in compressed sulfur Kui Wang, Hongjian Zhao, Guangtao Liu, Mi Zhou, Yinqi Chen, Qiushi Li, Guangchen Ma, Hongbo Wang, Russell J. Hemley and Yanming Ma Deriving a genetic regulatory network from an optimization principle Thomas R. Sokolowski, Thomas Gregor, William Bialek and Gašper Tkačik Sustainability Science Integrating climate and physical constraints into assessments of net capture from direct air capture facilities Patrick Shorey and Ahmed Abdulla Moisture-driven carbonation kinetics for ultrafast CO2 mineralization Yining Gao, Yong Tao, Gen Li, Peiliang Shen, Roland J.-M. Pellenq and Chi Sun Poon Social Sciences

Anthropology Earliest evidence of sedentism in the Antilles: Multiple isotope data from Canímar Abajo, Cuba Yadira Chinique de Armas, Silvia Teresita Hernández Godoy, Luis M. Viera Sanfiel, William M. Buhay and Jason E. Laffoon Family relations of Moche elite burials on the North Coast of Peru (~500 CE): Analyses of the Señora de Cao and relatives Jeffrey Quilter, Kelly Harkins, Régulo Fanco Jordan, Erik Marsh, Gabriel Prieto, John Verano, Steven LeBlanc, Nasreen Broomandkhoshbacht, John Krigbaum and Lars Fehren-Schmitz Demography The changing relationship between racial identity and skin color in Brazil Nicholas C. Freeman, Edward E. Telles and Rachel E. Goldberg Economic Sciences The unequal adoption of ChatGPT exacerbates existing inequalities among workers Anders Humlum and Emilie Vestergaard Political Sciences Income inequality and the erosion of democracy in the twenty-first century Eli G. Rau and Susan Stokes Psychological and Cognitive Sciences Personality differences between birth order categories and across sibship sizes Michael C. Ashton and Kibeom Lee The origin of color categories Daniel J. Garside, Audrey L. Y. Chang, Hannah M. Selwyn and Bevil R. Conway Social Sciences The effect of job loss on risky financial decision-making Samuel D. Hirshman, Abigail B. Sussman, Carlos Vazquez-Hernandez, Daniel O’Leary and Jennifer S. Trueblood Comparing cooperative geometric puzzle solving in ants versus humans Tabea Dreyer, Amir Haluts, Amos Korman, Nir Gov, Ehud Fonio and Ofer Feinerman Sustainability Science Energy–poverty–inequality SDGs: A large-scale household analysis and forecasting in China Cong Li, Minglai Li, Lin Zhang, Qiang Li, Hua Zheng and Marcus W. Feldman Biological Sciences

Agricultural Sciences PsDMAP1/PsTIP60-regulated H4K16ac is required for ROS-dependent virulence adaptation of Phytophthora sojae on host plants Fan Zhang, Shanshan Chen, Can Zhang, Zhiwen Wang, Jianqiang Miao, Tan Dai, Jianjun Hao and Xili Liu Carbon gain in upper but loss in deeper cropland soils across China over the last four decades Zhenghu Zhou, Chuankuan Wang, Yu’e Li, Xuhui Wang, Xinhua He, Minggang Xu and Andong Cai Anthropology Earliest evidence of sedentism in the Antilles: Multiple isotope data from Canímar Abajo, Cuba Yadira Chinique de Armas, Silvia Teresita Hernández Godoy, Luis M. Viera Sanfiel, William M. Buhay and Jason E. Laffoon Family relations of Moche elite burials on the North Coast of Peru (~500 CE): Analyses of the Señora de Cao and relatives Jeffrey Quilter, Kelly Harkins, Régulo Fanco Jordan, Erik Marsh, Gabriel Prieto, John Verano, Steven LeBlanc, Nasreen Broomandkhoshbacht, John Krigbaum and Lars Fehren-Schmitz Applied Biological Sciences Modular DNA origami–based electrochemical detection of DNA and proteins Byoung-jin Jeon, Matteo M. Guareschi, Jaimie Marie Stewart, Emily Wu, Ashwin Gopinath, Netzahualcóyotl Arroyo-Currás, Philippe Dauphin-Ducharme, Kevin W. Plaxco, Philip S. Lukeman and Paul W. K. Rothemund Computational-aided rational mutation design of pertuzumab to overcome active HER2 mutation S310F through antibody–drug conjugates Xuefei Bai, Lingyi Xu, Zhe Wang, Xinlei Zhuang, Jiangtao Ning, Yanping Sun, Haibin Wang, Yugang Guo, Yingchun Xu, Jiangtao Guo, Shuqing Chen and Liqiang Pan Deletion of metal transporter Zip14 reduces major histocompatibility complex II expression in murine small intestinal epithelial cells Felix R. Jimenez-Rondan, Courtney H. Ruggiero, Alberto Riva, Fahong Yu, Lauren S. Stafford, Tyler R. Cross, Joseph Larkin and Robert J. Cousins Biochemistry Unlocking the catalytic precision of ligand-controlled enzymatic halogenation Aisaraphon Phintha, April L. Lukowski and Pimchai Chaiyen Trojan horse peptide conjugates remodel the activity spectrum of clinical antibiotics Shangwen Luo, Xin-Rong Li, Xiao-Tong Gong, Alexey Kulikovsky, Feng Qu, Konstantinos Beis, Konstantin Severinov, Svetlana Dubiley, Xinxin Feng, Shi-Hui Dong and Satish K. Nair Dual-action kinase inhibitors influence p38α MAP kinase dephosphorylation Emily J. Stadnicki, Hannes Ludewig, Ramasamy P. Kumar, Xicong Wang, Youwei Qiao, Dorothee Kern and Niels Bradshaw Molecular basis of hemoglobin binding and heme removal in Corynebacterium diphtheriae Brendan J. Mahoney, Lindsey R. Lyman, Jordan Ford, Jess Soule, Nicole A. Cheung, Andrew K. Goring, Kat Ellis-Guardiola, Michael J. Collazo, Duilio Cascio, Hung Ton-That, Michael P. Schmitt and Robert T. Clubb Tungsten is utilized for lactate consumption and SCFA production by a dominant human gut microbe Eubacterium limosum Saisuki Putumbaka, Gerrit J. Schut, Michael P. Thorgersen, Farris L. Poole, Nana Shao, Dmitry A. Rodionov and Michael W. W. Adams Binding mode–guided development of high-performance antibodies targeting site-specific posttranslational modifications Mariapia Riso, Rohan N. Shah, Akiko Koide, Alexander J. Ruthenburg, Shohei Koide and Takamitsu Hattori Genesis and regulation of C-terminal cyclic imides from protein damage Wenqing Xu, Zhenguang Zhao, Matthew Su, Atul D. Jain, Hannah C. Lloyd, Ethan Yang Feng, Nick Cox and Christina M. Woo Tamsulosin ameliorates bone loss by inhibiting the release of Cl− through wedging into an allosteric site of TMEM16A Shiliang Li, Weijia Sun, Shuang Li, Lili Zhu, Shuai Guo, Jiaqi He, Yuheng Li, Chaoquan Tian, Zhenjiang Zhao, Tao Yu, Jianwei Li, Yiqing Zhang, Youlong Hai, Jiawen Wang, Yongjun Zheng, Rui Wang, Xiaoyong Hu, Shukuan Ling, Honglin Li and Yingxian Li Structural and functional dynamics of human cone cGMP-phosphodiesterase important for photopic vision Sneha Singh, Dhiraj Srivastava, Kimberly Boyd and Nikolai O. Artemyev Structures of methane and ammonia monooxygenases in native membranes Frank J. Tucci and Amy C. Rosenzweig TRAMP assembly alters the conformation and RNA binding of Mtr4 and Trf4-Air2 Joshua M. Denson, Naifu Zhang, Darby Ball, Kayla Thompson, Sean J. Johnson and Sheena D’Arcy Topological confinement by a membrane anchor suppresses phase separation into protein aggregates: Implications for prion diseases Kalpshree Gogte, Fatemeh Mamashli, Maria Georgina Herrera, Simon Kriegler, Verian Bader, Janine Kamps, Prerna Grover, Roland Winter, Konstanze F. Winklhofer and Jörg Tatzelt The CYLD–PARP1 feedback loop regulates DNA damage repair and chemosensitivity in breast cancer cells Miaomiao Zheng, Shuo Wang, Kexin Tang, Ruixue Kong, Xuemeng Wang, Jun Zhou, Yan Chen and Yijie Wang Electron transfer in polysaccharide monooxygenase catalysis Richard I. Sayler, William C. Thomas, Alexander J. Rose and Michael A. Marletta Integrin-activating Yersinia protein Invasin sustains long-term expansion of primary epithelial cells as 2D organoid sheets Joost J.A.P.M. Wijnakker, Gijs J.F. van Son, Daniel Krueger, Willine J. van de Wetering, Carmen Lopez-Iglesias, Robin Schreurs, Fenna van Rijt, Sangho Lim, Lin Lin, Peter J. Peters, Ralph R. Isberg, Claudia Y. Janda, Wim de Lau and Hans Clevers Biophysics and Computational Biology Confined cell migration along extracellular matrix space in vivo Oleksandr Chepizhko, Josep-Maria Armengol-Collado, Stephanie Alexander, Esther Wagena, Bettina Weigelin, Luca Giomi, Peter Friedl, Stefano Zapperi and Caterina A. M. La Porta Higher-order transient structures and the principle of dynamic connectivity in membrane signaling Yuxi Zhang and Roderick MacKinnon Higher-order transient membrane protein structures Yuxi Zhang, Hisham Mazal, Venkata Shiva Mandala, Gonzalo Pérez-Mitta, Vahid Sondoghdar, Christoph A. Haselwandter and Roderick MacKinnon Elucidation of a distinct photoreduction pathway in class II Arabidopsis thaliana photolyase Zhongneng Zhou, Zijing Chen, Xiu-Wen Kang, Bei Ding, Shuhua Zou, Siwei Tang, Yalin Zhou, Bingyao Wang and Dongping Zhong PhiSiCal-Checkup: A Bayesian framework to validate amino acid conformations within experimental protein structures Piyumi R. Amarasinghe, Lloyd Allison, Craig J. Morton, Peter J. Stuckey, Maria Garcia de la Banda, Arthur M. Lesk and Arun S. Konagurthu Structural basis of nearest-neighbor cooperativity in the ring-shaped gene regulatory protein TRAP from protein engineering and cryo-EM Weicheng Li, Haoyun Yang, Kye Stachowski, Andrew S. Norris, Katie Lichtenthal, Skyler Kelly, Paul Gollnick, Vicki H. Wysocki and Mark P. Foster A lever hypothesis for Synaptotagmin-1 action in neurotransmitter release Klaudia Jaczynska, Victoria Esser, Junjie Xu, Levent Sari, Milo M. Lin, Christian Rosenmund and Josep Rizo Predicting gene sequences with AI to study codon usage patterns Tomer Sidi, Shir Bahiri-Elitzur, Tamir Tuller and Rachel Kolodny Molecular basis of Spns1-mediated lysophospholipid transport from the lysosome Hongwen Chen, Hoa T. T. Ha, Nadia Elghobashi-Meinhardt, Nhung A. Le, Philip Schmiege, Long N. Nguyen and Xiaochun Li Dynamic binding of the bacterial chaperone Trigger factor to translating ribosomes in Escherichia coli Tora Hävermark, Mikhail Metelev, Erik Lundin, Ivan L. Volkov and Magnus Johansson CryoSeek II: Cryo-EM analysis of glycofibrils from freshwater reveals well-structured glycans coating linear tetrapeptide repeats Tongtong Wang, Wenze Huang, Kui Xu, Yitong Sun, Qiangfeng Cliff Zhang, Chuangye Yan, Zhangqiang Li and Nieng Yan Learning the language of antibody hypervariability Rohit Singh, Chiho Im, Yu Qiu, Brian Mackness, Abhinav Gupta, Taylor Joren, Samuel Sledzieski, Lena Erlach, Maria Wendt, Yves Fomekong Nanfack, Bryan Bryson and Bonnie Berger Cell Biology Endonuclease G promotes hepatic mitochondrial respiration by selectively increasing mitochondrial tRNAThr production Xihui Xu, Rozhin Penjweini, Lóránt Székvölgyi, Zsolt Karányi, Anne-Marie Heckel, Devikala Gurusamy, Dóra Varga, Shutong Yang, Alexandra L. Brown, Wenqi Cui, Jinsung Park, Dénes Nagy, Maren C. Podszun, Sarah Yang, Komudi Singh, Stephen P. Ashcroft, Jeonghan Kim, Myung K. Kim, Ivan Tarassov, Jun Zhu, Andrew Philp, Yaron Rotman, Jay R. Knutson, Nina Entelis and Jay H. Chung Tsg101 mimicry of canonical E2 enzymes underlies its role in ubiquitin signaling David A. Nyenhuis, Susan M. Watanabe, Nico Tjandra and Carol A. Carter Deciphering the role of the MALT1–RC3H1 axis in regulating GPX4 protein stability Jun Wang, Long Liao, Beiping Miao, Bo Yang, Botai Li, Xuhui Ma, Annika Fitz, Shanshan Wu, Jia He, Qianqian Zhang, Shuyi Ji, Guangzhi Jin, Jianming Zhang, Ying Cao, Hui Wang, Wenxin Qin, Chong Sun, René Bernards and Cun Wang Developmental Biology A minimal vertex model explains how the amnioserosa avoids fluidization during Drosophila dorsal closure Indrajit Tah, Daniel Haertter, Janice M. Crawford, Daniel P. Kiehart, Christoph F. Schmidt and Andrea J. Liu Deep conservation complemented by novelty and innovation in the insect eye ground plan Ke Gao, Antoine Donati, Julia Ainsworth, Di Wu, Eleanor R. Terner and Michael W. Perry Complex tissue regeneration in Lophuromys reveals a phylogenetic signal for enhanced regenerative ability in deomyine rodents Brennan Riddell, Molly McDonough, Adam Ferguson, John M. Kimani, Thomas R. Gawriluk, Chi Peng, Stephen G. Kiama, Vanessa O. Ezenwa and Ashley W. Seifert Gonadal sex and temperature independently influence germ cell differentiation and meiotic progression in Trachemys scripta Talia Hatkevich, Boris M. Tezak, Rafael D. Acemel, Vicky Wai Yee Chung, Dario G. Lupiáñez and Blanche Capel RAP-2 and CNH-MAP4 Kinase MIG-15 confer resistance in bystander epithelium to cell-fate transformation by excess Ras or Notch activity Razan A. Fakieh and David J. Reiner A mechanosensitive circuit of FAK, ROCK, and ERK controls biomineral growth and morphology in the sea urchin embryo Majed Layous, Tsvia Gildor, Tovah Nehrer, Areen Qassem, Haguy Wolfenson and Smadar Ben-Tabou de-Leon Ecology Nocturnal camouflage through background matching against moonlight Juan J. Negro, Salvador Bará, David Galadí-Enríquez, Juan Luis Nieves, Miguel A. Martínez-Domingo, Alejandro Ferrero, Joaquín Campos, Carmen Bao-Varela, Eduard Masana and Carlos Camacho Comparing cooperative geometric puzzle solving in ants versus humans Tabea Dreyer, Amir Haluts, Amos Korman, Nir Gov, Ehud Fonio and Ofer Feinerman Metabolic enhancement contributed by horizontal gene transfer is essential for dietary specialization in leaf beetles Yuxin Zhang, Chengjie Tu, Jianyang Bai, Xiayu Li, Ziyue Sun and Letian Xu Environmental Sciences Persistent humid climate favored the Qin and Western Han Dynasties in China around 2,200 y ago Chun Qin, Bao Yang, Achim Bräuning, Fredrik Charpentier Ljungqvist, Timothy J. Osborn, Vladimir Shishov, Minhui He, Shuyuan Kang, Lea Schneider, Jan Esper, Ulf Büntgen, Jussi Grießinger, Danqing Huang, Peng Zhang, Stefanie Talento, Elena Xoplaki, Jürg Luterbacher and Nils Chr. Stenseth Evolution X*Y females exhibit steeper reproductive senescence in the African pygmy mouse Jean-François Lemaître, Yann Voituron, Léa Herpe and Frédéric Veyrunes Evolution takes multiple paths to evolvability when facing environmental change Bhaskar Kumawat, Alexander Lalejini, Monica M. Acosta and Luis Zaman Divergence time and environmental similarity predict the strength of morphological convergence in stick and leaf insects Romain P. Boisseau, Sven Bradler and Douglas J. Emlen Genetics Oncogenic IDH1mut drives robust loss of histone acetylation and increases chromatin heterogeneity Noa Furth, Niv Cohen, Avishay Spitzer, Tomer-Meir Salame, Bareket Dassa, Tevie Mehlman, Alexander Brandis, Arieh Moussaieff, Dinorah Friedmann-Morvinski, Maria G. Castro, Jerome Fortin, Mario L. Suvà, Itay Tirosh, Ayelet Erez, Guy Ron and Efrat Shema An animal model recapitulates human hepatic diseases associated with GATA6 mutations Wenpeng Shi, Xiaogui Yi, Hua Ruan, Donglei Wang, Dan Wu, Pengfei Jiang, Lisha Luo, Xirui Ma, Faming Jiang, Cairui Li, Weinan Wu, Lingfei Luo, Li Li, Guixue Wang, Juhui Qiu and Honghui Huang A mutant ASXL1-BAP1-EHMT complex contributes to heterochromatin dysfunction in clonal hematopoiesis and chronic monomyelocytic leukemia Zhen Dong, Hugo Sepulveda, Leo J. Arteaga-Vazquez, Chad Blouin, Jenna Fernandez, Moritz Binder, Wen-Chien Chou, Hwei-Fang Tien, Mrinal M. Patnaik, Geoffrey J. Faulkner, Samuel A. Myers and Anjana Rao Immunology and Inflammation Affinity maturation endows potent activity onto class 6 SARS-CoV-2 broadly neutralizing antibodies Ohan Mazigi, David B. Langley, Jake Y. Henry, Deborah L. Burnett, Meghna Sobti, Gregory J. Walker, Romain Rouet, Harikrishnan Balachandran, Helen Lenthall, Jennifer Jackson, Stephanie Ubiparipovic, Peter Schofield, Simon H. J. Brown, Sebastian R. Schulz, Markus Hoffmann, Stefan Pöhlmann, Jeffrey Post, Marianne Martinello, Golo Ahlenstiel, Anthony Kelleher, William D. Rawlinson, Stuart G. Turville, Rowena A. Bull, Alastair G. Stewart, Hans-Martin Jäck, Christopher C. Goodnow and Daniel Christ Medical Sciences Efficacy of GABA aminotransferase inactivator OV329 in models of neuropathic and inflammatory pain without tolerance or addiction Jonah L. Wirt, Luana Assis Ferreira, Carlos Henrique Alves Jesus, Taylor J. Woodward, Idaira Oliva, Zhili Xu, Jonathon D. Crystal, Robert H. Pepin, Richard B. Silverman and Andrea G. Hohmann Salmonella infection accelerates postnatal maturation of the intestinal epithelium Stefan Schlößer, Anna-Lena Ullrich, Nastaran Fazel Modares, Matthias A. Schmitz, Johannes Schöneich, Kaiyi Zhang, Isabel Richter, Laura Robrahn, Sarah Schraven, James S. Nagai, Sven-Bastiaan Haange, Susan A. V. Jennings, Thomas Clavel, Ulrike Rolle-Kampczyk, Fabian Kiessling, Ivan G. Costa, Vanesa Muncan, Urska Repnik, Martin von Bergen, Aline Dupont and Mathias W. Hornef Hydroxychloroquine prevents resistance and potentiates the antitumor effect of SHP2 inhibition in NF1-associated malignant peripheral nerve sheath tumors Sameer Farouk Sait, Kwan Ho Tang, Steven P. Angus, Rebecca Brown, Daochun Sun, Xuanhua Xie, Charlene Iltis, Michelle Lien, Nicholas D. Socci, Tejus A. Bale, Christopher Davis, Shelley A. H. Dixon, Chi Zhang, D. Wade Clapp, Benjamin G. Neel and Luis F. Parada Reconciling heterogeneous dengue virus infection risk estimates from different study designs Angkana T. Huang, Darunee Buddhari, Surachai Kaewhiran, Sopon Iamsirithaworn, Direk Khampaen, Aaron Farmer, Stefan Fernandez, Stephen J. Thomas, Isabel Rodriguez-Barraquer, Taweewun Hunsawong, Anon Srikiatkhachorn, Gabriel Ribeiro dos Santos, Megan O’Driscoll, Marco Hamins-Puertolas, Timothy Endy, Alan L. Rothman, Derek A. T. Cummings, Kathryn Anderson and Henrik Salje Mechanism-guided engineering of a minimal biological particle for genome editing Wayne Ngo, Julia Peukes, Alisha Baldwin, Zhiwei Wayne Xue, Sidney Hwang, Robert R. Stickels, Zhi Lin, Ansuman T. Satpathy, James A. Wells, Randy Schekman, Eva Nogales and Jennifer A. Doudna Mitochondrial DNA lineages determine tumor progression through T cell reactive oxygen signaling Tal Yardeni, Arnold Z. Olali, Hsiao-Wen Chen, Liqing Wang, Jeffrey A. Halton, Angi Zenab, Ryan Morrow, Arrienne Butic, Deborah G. Murdock, Katrina G. Waymire, Grant R. MacGregor, Ben Boursi, Ulf H. Beier, Wayne W. Hancock and Douglas C. Wallace Microbiology Structural insight into sodium ion pathway in the bacterial flagellar stator from marine Vibrio Tatsuro Nishikino, Norihiro Takekawa, Jun-ichi Kishikawa, Mika Hirose, Seiji Kojima, Michio Homma, Takayuki Kato and Katsumi Imada Palmitoylation-dependent association with Annexin II directs hepatitis E virus ORF3 sorting into vesicles and quasi-enveloped virions Xing Liu, Tianxu Liu, Zhen Shao, Xiaoyan Xiong, Shuhui Qi, Junyong Guan, Menghang Wang, Yan-Dong Tang, Zongdi Feng, Lin Wang and Xin Yin Tetrameric PilZ protein stabilizes stator ring in complex flagellar motor and is required for motility in Campylobacter jejuni Yuanyuan Chen, Shoichi Tachiyama, Yuqian Li, Xueyin Feng, Hang Zhao, Yanmin Wu, Yu Guo, María Lara-Tejero, Canfeng Hua, Jun Liu and Beile Gao In situ architecture of a nucleoid-associated biomolecular co-condensate that regulates bacterial cell division Peng Xu, Dominik Schumacher, Chuan Liu, Andrea Harms, Marcel Dickmanns, Florian Beck, Jürgen M. Plitzko, Wolfgang Baumeister and Lotte Søgaard-Andersen Structure-guided design and synthesis of C22- and C32-modified FK520 analogs with enhanced activity against human pathogenic fungi Patrick A. Dome, Pyeonghwa Jeong, Gibeom Nam, Hongjun Jang, Angela Rivera, Anna Floyd Averette, Eunchong Park, Tzu-Chieh Liao, Maria Ciofani, Jianli Wu, Jen-Tsan Ashley Chi, Ronald A. Venters, Hyun-Ju Park, William J. Steinbach, Praveen R. Juvvadi, Joseph Heitman and Jiyong Hong Neuroscience Oppositional and competitive instigation of hippocampal synaptic plasticity by the VTA and locus coeruleus Hardy Hagena and Denise Manahan-Vaughan Retinal ganglion cells encode the direction of motion outside their classical receptive field Serena Riccitelli, Hadar Yaakov, Alina S. Heukamp, Lea Ankri and Michal Rivlin-Etzion MYO7A is required for the functional integrity of the mechanoelectrical transduction complex in hair cells of the adult cochlea Anna Underhill, Samuel Webb, Fiorella C. Grandi, Jing-Yi Jeng, Jacques B. de Monvel, Baptiste Plion, Adam J. Carlton, Ana E. Amariutei, Niovi Voulgari, Francesca De Faveri, Federico Ceriani, Mirna Mustapha, Stuart L. Johnson, Saaid Safieddine, Corné J. Kros and Walter Marcotti VCP controls KCC2 degradation through FAF1 recruitment and accelerates emergence from anesthesia Peng Chen, Jiang-Jian Hu, Yuexin Liu, Boxu Cao and Xue-Jun Song Aberrant neuronal hyperactivation causes an age-dependent behavioral decline in Caenorhabditis elegans Binta Maria Aleogho, Mizuho Mohri, Moon Sun Jang, Sachio Tsukada, Yana Al-Hebri, Hironori J. Matsuyama, Yuki Tsukada, Ikue Mori and Kentaro Noma Molecular mechanism governing the plasticity of use-dependent spike broadening in dorsal root ganglion neurons Tyler D. Alexander, Stephen Tymanskyj, Kyle J. Kennedy, Leonard K. Kaczmarek and Manuel Covarrubias A detailed spatiotemporal atlas of the white matter tracts for the fetal brain Camilo Calixto, Matheus Dorigatti Soldatelli, Camilo Jaimes, Lana Pierotich, Simon K. Warfield, Ali Gholipour and Davood Karimi Individual differences elucidate the perceptual benefits associated with robust temporal fine-structure processing Agudemu Borjigin and Hari M. Bharadwaj Population encoding of observed and actual somatosensations in the human posterior parietal cortex Srinivas Chivukula, Tyson Aflalo, Carey Zhang, Emily R. Rosario, Ausaf Bari, Nader Pouratian and Richard A. Andersen Synapse-specific catecholaminergic modulation of neuronal glutamate release Dariya Bakshinska, William YuChen Liu, Ryan Schultz, R. Steven Stowers, Adam Hoagland, Caroline Cypranowska, Cherise Stanley, Susan H. Younger, Zachary L. Newman and Ehud Y. Isacoff Physiology RNAi of the elastomeric protein resilin reduces jump velocity and resilience to damage in locusts Stephen M. Rogers, Darron A. Cullen, David Labonte, Gregory P. Sutton, Jozef J. M. Vanden Broeck and Malcolm Burrows Protein dynamics underlies strong temperature dependence of heat receptors Andrew Njagi Mugo, Ryan Chou and Feng Qin Comparing integrative ventilatory and renal acid–base acclimatization in lowlanders and Tibetan highlanders during ascent to 4,300 m Nicole A. Johnson, Jessica A. Dickenson, Benjamin W.L. MacKenzie, Rodion Isakovich, Anne Kalker, Janne Bouten, Nicholas D.J. Strzalkowski, Taylor S. Harman, Pontus Holmström, Ajaya J. Kunwar, Nilam Thakur, Sunil Dhungel, Nima Sherpa, Abigail W. Bigham, Tom D. Brutsaert and Trevor A. Day Plant Biology The carnivorous plant Genlisea harnesses active particle dynamics to prey on microfauna José Martín-Roca, C. Miguel Barriuso G., Raúl Martínez Fernández, Camila Betterelli Giuliano, Rongjing Zhang, Chantal Valeriani and Laurence G. Wilson ANAC044 orchestrates mitochondrial stress signaling to trigger iron-induced stem cell death in root meristems Juanmei Yan, Zhihang Feng, Yihui Xiao, Ming Zhou, Xiaobo Zhao, Xianyong Lin, Weiming Shi, Wolfgang Busch and Baohai Li Diverse plant RNAs coat Arabidopsis leaves and are distinct from apoplastic RNAs M. Lucía Borniego, Meenu Singla-Rastogi, Patricia Baldrich, Megha Hastantram Sampangi-Ramaiah, Hana Zand Karimi, Madison McGregor, Blake C. Meyers and Roger W. Innes Conservation of symbiotic signaling since the most recent common ancestor of land plants Tatiana Vernié, Mélanie Rich, Tifenn Pellen, Eve Teyssier, Vincent Garrigues, Lucie Chauderon, Lauréna Medioni, Fabian van Beveren, Cyril Libourel, Jean Keller, Camille Girou, Corinne Lefort, Aurélie Le Ru, Yves Martinez, Didier Reinhardt, Kyoichi Kodama, Shota Shimazaki, Patrice Morel, Junko Kyozuka, Malick Mbengue, Michiel Vandenbussche and Pierre-Marc Delaux Dissecting the cellular architecture and genetic circuitry of the soybean seed Julie M. Pelletier, Min Chen, Jer-Young Lin, Brandon Le, Ryan C. Kirkbride, Jungim Hur, Tina Wang, Shu-Heng Chang, Alexander Olson, Lachezar Nikolov, Robert B. Goldberg and John J. Harada Population Biology Climate change could amplify weak synchrony in large marine ecosystems Vadim A. Karatayev, Stephan B. Munch, Tanya L. Rogers and Daniel C. Reuman Psychological and Cognitive Sciences The origin of color categories Daniel J. Garside, Audrey L. Y. Chang, Hannah M. Selwyn and Bevil R. Conway Memory control deficits in the sleep-deprived human brain Marcus O. Harrington, Theodoros Karapanagiotidis, Lauryn Phillips, Jonathan Smallwood, Michael C. Anderson and Scott A. Cairney Sustainability Science Collaborative management partnerships strongly decreased deforestation in the most at-risk protected areas in Africa since 2000 Sébastien Desbureaux, Ibrahim Kabore, Giulia Vaglietti, Mujon Baghai, Peter Lindsey, Ashley Robson, Philippe Delacote and Antoine Leblois Systems Biology Chromatin enables precise and scalable gene regulation with factors of limited specificity Mindy Liu Perkins, Justin Crocker and Gašper Tkačik Human brain dynamics are shaped by rare long-range connections over and above cortical geometry Jakub Vohryzek, Yonatan Sanz-Perl, Morten L. Kringelbach and Gustavo Deco The proteome is a terminal electron acceptor Avi I. Flamholz, Akshit Goyal, Woodward W. Fischer, Dianne K. Newman and Rob Phillips Corrections

Correction for Armstrong et al., Genetic differentiation and precolonial Indigenous cultivation of hazelnut (Corylus cornuta, Betulaceae) in western North America Correction for Yun et al., GPCR targeting of E3 ubiquitin ligase MDM2 by inactive β-arrestin Correction for Bartesaghi et al., Inhibition of oxidative metabolism leads to p53 genetic inactivation and transformation in neural stem cells Correction for Zhou et al., A genome-wide microRNA screen identifies the microRNA-183/96/182 cluster as a modulator of circadian rhythms Correction for Ritz et al., Social anxiety disorder-associated gut microbiota increases social fear Correction for Huo et al., Hierarchical behavior control by a single class of interneurons

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