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From: PNAS <no-reply@pnas.nas.edu>
Date: April 15, 2025 at 1:08:56 PM GMT-3
To: mhallak@fcq.unc.edu.ar
Subject: Proceedings of the National Academy of Sciences Vol. 122, No. 15, April 15, 2025 is now available online
Reply-To: no-reply@pnas.nas.edu

Proceedings of the National Academy of Sciences
PNAS

New Issue Available

PNAS

April 15, 2025  |  VOL.122  |  NO.15

View Table of contents

This Week in PNAS

In This Issue

Opinion

The importance of playing the long game when it comes to pandemic surveillance

Commentaries

Coupling between the lever arm and active site via an N-terminal extension tunes force sensitivity in the myosin-1 family

A continental view of climate effects on lakes

Enhanced polymorph metastability drives glycine nucleation in aqueous salt solutions

Mixing microbiomes in vitro reveals rules of community assembly

Perspective

Richardson’s law and the origins of alcohol research

Letters

The impact of sampling bias on preferences for skewed distributions in decisions from experience

Reply to Vanunu and Newell: The frequent-winner effect is necessary to explain experience-based decisions

Brief Report

Structural basis of ZP2-targeted female nonhormonal contraception

Physical Sciences

Applied Mathematics

Privacy for free in the overparameterized regime

Applied Physical Sciences

Melting of nonreciprocal solids: How dislocations propel and fission in flowing crystals

Self-organized institutions in evolutionary dynamical-systems games

Biophysics and Computational Biology

Chemically active wetting

Substrate stress relaxation regulates monolayer fluidity and leader cell formation for collectively migrating epithelia

NAL1 forms a molecular cage to regulate FZP phase separation

Chemistry

In situ generated hydrogen-bonding microenvironment in functionalized MOF nanosheets for enhanced CO2 electroreduction

Tetrathienylethene-based porous framework composites for boosting photocatalytic antibacterial activity

Glassy ionogels with high compressibility and strength for impact protection

Unsupervised learning of structural relaxation in supercooled liquids from short-term fluctuations

On the hidden transient interphase in metal anodes: Dynamic precipitation controls electrochemical interfaces in batteries

Proximity-activated DNA scanning encoded sequencing for massive access to membrane proteins nanoscale organization

Exploring RNA destabilization mechanisms in biomolecular condensates through atomistic simulations

Uniform elementary fibrils in diverse plant cell walls

Earth, Atmospheric, and Planetary Sciences

Phosphatic stromatoporoid sponges formed reefs ~480 Mya

Seismic fault slip at depths simulated by high-velocity friction experiments under hydrothermal conditions

Transferring climate change physical knowledge

Engineering

The fruit fly, Drosophila melanogaster, as a microrobotics platform

Ultra narrowband geometric-phase resonant metasurfaces

Motion artifact–controlled micro–brain sensors between hair follicles for persistent augmented reality brain–computer interfaces

Maximizing underwater energy harvesting efficiency using flexible solar cells: A pathway to sustainable ocean power

Mathematics

Closure of orbits of the pure mapping class group in the character variety

On Hodge polynomials for nonalgebraic complex manifolds

Physics

Degenerate domain walls in supersymmetric theories

Probing ultraweak in-plane magnetic anisotropy within a two-dimensional layered antiferromagnet

Emergent gauge fields in band insulators

Social Sciences

Anthropology

Indigenous Knowledge as a sole data source in habitat selection functions

Demography

Global subnational estimates of migration of scientists reveal large disparities in internal and international flows

Psychological and Cognitive Sciences

A computational analysis of lexical elaboration across languages

Whole-brain white matter variation across childhood environments

Cortical scaling of the neonatal brain in typical and altered development

Multiplexing of cognitive encoding by oculomotor networks leads to incidental gaze shifts

Social Sciences

New Advanced Placement course designed to broaden access promotes participation and demographic diversity in computer science education

Biological Sciences

Anthropology

Enamel–dentine junction morphology reveals population replacement and mobility in the late prehistoric Middle Nile Valley

Biochemistry

Proximity-activated DNA scanning encoded sequencing for massive access to membrane proteins nanoscale organization

An integrated AI knowledge graph framework of bacterial enzymology and metabolism

Structural and functional characterization of the brain-specific dynamin superfamily member RNF112

Structure of a Gcn2 dimer in complex with the large 60S ribosomal subunit

Biophysics and Computational Biology

Exploring RNA destabilization mechanisms in biomolecular condensates through atomistic simulations

Substrate stress relaxation regulates monolayer fluidity and leader cell formation for collectively migrating epithelia

Structural basis of the cysteinyl leukotriene receptor type 2 activation by LTD4

Structural basis for immune cell binding of Fusobacterium nucleatum via the trimeric autotransporter adhesin CbpF

Conformational signatures induced by ubiquitin modification in the amyloid-forming tau repeat domain

Roquin exhibits opposing effects on RNA stem-loop stability through its two ROQ domain binding sites

Cell Biology

Downregulation of Nesprin1 by Runx2 deficiency is critical for the development of skeletal laminopathy-like pathology

Alpha-tubulin tails regulate axoneme differentiation

FAO-fueled OXPHOS and NRF2-mediated stress resilience in MICs drive lymph node metastasis

ID3 enhances PD-L1 expression by restructuring MYC to promote colorectal cancer immune evasion

Developmental Biology

Bourbon and Mycbp function with Otu to promote Sxl protein expression in the Drosophila female germline

Perturbing nuclear glycosylation in the mouse preimplantation embryo slows down embryonic development

Arf1 and ARFGEF2/Sec71 control neuroblast polarity by anchoring nonmuscle myosin II

Two transcription factors play critical roles in mediating epigenetic regulation of fruit ripening in tomato

Ecology

Indigenous Knowledge as a sole data source in habitat selection functions

Interactions among nutrients govern the global grassland biomass–precipitation relationship

Philip A. FayLaureano A. GherardiLaura YahdjianPeter B. AdlerJonathan D. BakkerSiddharth BharathElizabeth T. BorerW. Stanley HarpoleErika Hersch-GreenTravis E. HuxmanAndrew S. MacDougallAnita C. RischEric W. SeabloomSumanta BagchiIsabel C. BarrioLori BiedermanYvonne M. BuckleyMiguel N. BugalhoMaria C. CaldeiraJane A. CatfordQingQing ChenElsa E. ClelandScott L. CollinsPedro DaleoChristopher R. DickmanIan DonohueMary E. DuPreNico EisenhauerAnu EskelinenNicole HagenahYann HautierRobert W. HeckmanIngibjörg S. JónsdóttirJohannes M. H. KnopsRamesh LaunganiJason P. MartinaRebecca L. McCulleyJohn W. MorganHarry Olde VenterinkPablo L. PeriSally A. PowerXavier RaynaudZhengwei RenChristiane RoscherMelinda D. SmithMarie SpohnCarly J. StevensMichelle J. TedderRisto VirtanenGlenda M. Wardle and George R. Wheeler

Environmental Sciences

The genetic legacy of a global marine invader

Evolution

Phosphatic stromatoporoid sponges formed reefs ~480 Mya

Self-organized institutions in evolutionary dynamical-systems games

Host ZAP activity correlates with the levels of CpG suppression in primate lentiviruses

Epistasis-mediated compensatory evolution in a fitness landscape with adaptational tradeoffs

Evolutionary divergent kinetoplast genome structure and RNA editing patterns in the trypanosomatid Vickermania

Genetics

SRP19 and the protein secretion machinery is a targetable vulnerability in cancers with APC loss

Immunology and Inflammation

A monoclonal anti-hemagglutinin stem antibody modified with zanamivir protects against both influenza A and B viruses

FLIPL permits apoptotic and inflammatory signaling and inhibits necroptosis in mice without Caspase-8 oligomerization

Medical Sciences

Biallelic variants in the conserved ribosomal protein chaperone gene PDCD2 are associated with hydrops fetalis and early pregnancy loss

Nat10-mediated N4-acetylcytidine modification enhances Nfatc1 translation to exacerbate osteoclastogenesis in postmenopausal osteoporosis

Neddylation modification stabilizes LC3B by antagonizing its ubiquitin-mediated degradation and promoting autophagy in skin

Compositional and topological determinants of a physiological Ashwell–Morell receptor ligand

Microbiology

Bispecific antibodies against the hepatitis C virus E1E2 envelope glycoprotein

Pulsatile basal gene expression as a fitness determinant in bacteria

DprA recruits ComM to facilitate recombination during natural transformation in Gram-negative bacteria

Neuroscience

The fruit fly, Drosophila melanogaster, as a microrobotics platform

Whole-brain white matter variation across childhood environments

Cortical scaling of the neonatal brain in typical and altered development

Multiplexing of cognitive encoding by oculomotor networks leads to incidental gaze shifts

Activity of spinal RORβ neurons is related to functional improvements following combination treatment after complete SCI

Astrocytic Ryk signaling coordinates scarring and wound healing after spinal cord injury

Inactivation of microglial LXRβ in early postnatal mice impairs microglia homeostasis and causes long-lasting cognitive dysfunction

Plant Biology

NAL1 forms a molecular cage to regulate FZP phase separation

Uniform elementary fibrils in diverse plant cell walls

ZmGCT1/2 negatively regulate drought tolerance in maize by inhibiting ZmSLAC1 to maintain guard cell turgor

Psychological and Cognitive Sciences

The Beholder’s Share: Bridging art and neuroscience to study individual differences in subjective experience

Corrections

Correction for Kumar et al., Cluster dynamical mean-field study of intra-unit-cell charge nematicity in hole-doped cuprates

Correction for Wijnakker et al., Integrin-activating Yersinia protein Invasin sustains long-term expansion of primary epithelial cells as 2D organoid sheets

Correction for Zhang et al., HIPK2 phosphorylates HDAC3 for NF-κB acetylation to ameliorate colitis-associated colorectal carcinoma and sepsis

Correction for Du et al., The RNA-binding protein RBPMS inhibits smooth muscle cell–driven vascular remodeling in atherosclerosis and vascular injury

Correction for Epstein-Barash et al., Prolonged duration local anesthesia with minimal toxicity

Correction for He et al., Radiation-induced cellular plasticity primes glioblastoma for forskolin-mediated differentiation

Correction for Johnson et al., Comparing integrative ventilatory and renal acid–base acclimatization in lowlanders and Tibetan highlanders during ascent to 4,300 m

SI Correction

Correction to Supporting Information for Karayel et al., Impairment of DET1 causes neurological defects and lethality in mice and humans

PNAS
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