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Fwd: Rapid Review Quiz: The Gut Microbiome and Its Effect on Health
by Marta Hallak April 3, 2025

April 3, 2025

Sent from my iPad Begin forwarded message: > From: "Medscape Rapid Review" <rapidreview(a)mail.medscape.com> > Date: April 3, 2025 at 9:02:59 AM GMT-3 > To: <MHALLAK(a)FCQ.UNC.EDU.AR> > Subject: Rapid Review Quiz: The Gut Microbiome and Its Effect on Health > Reply-To: "Medscape from WebMD" <reply-fe8d137376610d7b74-57827_HTML-143824748-7000859-2002(a)mail.medscape.com> > > > > > Rapid Review Quiz > > Rapid Review Quiz: The Gut … [View More]

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Fwd: Autism Symptoms in Mice Linked To Nerve Proteins Falling Out of Equilibrium
by Marta Hallak April 3, 2025

April 3, 2025

Sent from my iPad Begin forwarded message: > From: Genetic Engineering & Biotechnology News <gen(a)genmail.co> > Date: April 2, 2025 at 11:01:58 AM GMT-3 > To: mxh5000(a)gmail.com > Subject: Autism Symptoms in Mice Linked To Nerve Proteins Falling Out of Equilibrium > Reply-To: gen(a)genmail.co > > > View in browser > > > TOP STORIES > Wednesday, April 2, 2025 > > > > Autism Symptoms in Mice … [View More]Linked To Nerve Proteins Falling Out of Equilibrium > > Scientists found that autism symptoms in mice arise when a pair of nerve proteins falls out of equilibrium. The collective findings demonstrated that MDGA2 deficiency results in aberrant BDNF/TrkB activation, ultimately leading to ASD-like phenotypes. + MORE > > > FDA, NIH, CDC Stagger as HHS Axe Falls, Eliminating 10,000 Jobs > > The 10,000 jobs being eliminated include 3,500 positions at the FDA, 2,400 at the U.S. Centers for Disease Control and Prevention (CDC), and 1,200 at the NIH. + MORE > > > IDT Lengthens DNA Offerings with Elegen Partnership > > IDT and Elegen partner to launch an early access program offering long, clonal gene synthesis and high-complexity genes up to 15 kb. Customers can order through IDT and the DNA will be manufactured and shipped from Elegen. + MORE > > > ALS Consortium Launches Website to Advance ALS Research > > ASSESS ALL ALS is for people living with the disease and healthy people who will act as comparators. PREVENT ALL ALS is for people who may be at genetic risk for ALS. + MORE > > > SPONSORED > Expand Your NGS Multiplexing Capabilities > > Dramatically lower your sequencing costs without changing your library prep protocol with the set of 1,536 NEXTFLEX™ UDI adapters. Alternatively, the NEXTFLEX UDI-UMI adapters enable rare variant analysis in PCR-free libraries. Learn more. > For research use only. Not for use in diagnostic procedures. + MORE > Input Determines Output: Building a Protein Expression Platform > > To find out more about ongoing advances in developing cell lines for protein expression, GEN talked with three experts from China, Denmark, and the U.S. + MORE > > > > Practicing Viral Vigilance Over Cell Culture-Based Processes > > Researchers envision ongoing advances in monitoring EBV and OvHV-2 viruses. For example, scientists point out that “incorporating high-throughput sequencing and single-cell analysis into EBV and OvHV-2 detection processes could reveal viral diversity within cell cultures.” + MORE > > > UPCOMING WEBINARS > NGS Workflows for Expedited Development & Manufacturing of Therapeutic Antibodies > > In TODAY's GEN webinar, scientists from Moderna and seqWell will present several applications of a fully scalable, one-step NGS library preparation workflow that span antibody development and biomanufacturing. + MORE > > > An Automated, High-Throughput Approach for Stability Testing in Protein, Cell, and Gene Therapeutics > > In this GEN webinar, Dr. Karessa White will explore how the Aura platforms offer rapid screening to assess biological aggregation and extrinsic particulate contamination in protein, cell and gene therapeutics, from initial product selection to the manufacturing stage. + MORE > > > > > > > Genetic Engineering & Biotechnology News > Mary Ann Liebert, Inc., a Sage Company > 140 Huguenot Street > New Rochelle, NY 10801 > You have received this email at mxh5000(a)gmail.com > Unsubscribe Manage Preferences [View Less]

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Fwd: Autism Symptoms in Mice Linked To Nerve Proteins Falling Out of Equilibrium
by Marta Hallak April 2, 2025

April 2, 2025

Sent from my iPad Begin forwarded message: > From: Genetic Engineering & Biotechnology News <gen(a)genmail.co> > Date: April 2, 2025 at 11:01:58 AM GMT-3 > To: mxh5000(a)gmail.com > Subject: Autism Symptoms in Mice Linked To Nerve Proteins Falling Out of Equilibrium > Reply-To: gen(a)genmail.co > > > View in browser > > > TOP STORIES > Wednesday, April 2, 2025 > > > > Autism Symptoms in Mice … [View More]Linked To Nerve Proteins Falling Out of Equilibrium > > Scientists found that autism symptoms in mice arise when a pair of nerve proteins falls out of equilibrium. The collective findings demonstrated that MDGA2 deficiency results in aberrant BDNF/TrkB activation, ultimately leading to ASD-like phenotypes. + MORE > > > FDA, NIH, CDC Stagger as HHS Axe Falls, Eliminating 10,000 Jobs > > The 10,000 jobs being eliminated include 3,500 positions at the FDA, 2,400 at the U.S. Centers for Disease Control and Prevention (CDC), and 1,200 at the NIH. + MORE > > > IDT Lengthens DNA Offerings with Elegen Partnership > > IDT and Elegen partner to launch an early access program offering long, clonal gene synthesis and high-complexity genes up to 15 kb. Customers can order through IDT and the DNA will be manufactured and shipped from Elegen. + MORE > > > ALS Consortium Launches Website to Advance ALS Research > > ASSESS ALL ALS is for people living with the disease and healthy people who will act as comparators. PREVENT ALL ALS is for people who may be at genetic risk for ALS. + MORE > > > SPONSORED > Expand Your NGS Multiplexing Capabilities > > Dramatically lower your sequencing costs without changing your library prep protocol with the set of 1,536 NEXTFLEX™ UDI adapters. Alternatively, the NEXTFLEX UDI-UMI adapters enable rare variant analysis in PCR-free libraries. Learn more. > For research use only. Not for use in diagnostic procedures. + MORE > Input Determines Output: Building a Protein Expression Platform > > To find out more about ongoing advances in developing cell lines for protein expression, GEN talked with three experts from China, Denmark, and the U.S. + MORE > > > > Practicing Viral Vigilance Over Cell Culture-Based Processes > > Researchers envision ongoing advances in monitoring EBV and OvHV-2 viruses. For example, scientists point out that “incorporating high-throughput sequencing and single-cell analysis into EBV and OvHV-2 detection processes could reveal viral diversity within cell cultures.” + MORE > > > UPCOMING WEBINARS > NGS Workflows for Expedited Development & Manufacturing of Therapeutic Antibodies > > In TODAY's GEN webinar, scientists from Moderna and seqWell will present several applications of a fully scalable, one-step NGS library preparation workflow that span antibody development and biomanufacturing. + MORE > > > An Automated, High-Throughput Approach for Stability Testing in Protein, Cell, and Gene Therapeutics > > In this GEN webinar, Dr. Karessa White will explore how the Aura platforms offer rapid screening to assess biological aggregation and extrinsic particulate contamination in protein, cell and gene therapeutics, from initial product selection to the manufacturing stage. + MORE > > > > > > > Genetic Engineering & Biotechnology News > Mary Ann Liebert, Inc., a Sage Company > 140 Huguenot Street > New Rochelle, NY 10801 > You have received this email at mxh5000(a)gmail.com > Unsubscribe Manage Preferences [View Less]

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llave de aula B14 requerida
by Rafael Gustavo OLIVEIRA April 1, 2025

April 1, 2025

Hola gente, alguien sabrá sobre el paradero de alguna llave de la B14? Saludos Rafa -- Dr. Rafael Gustavo Oliveira CIQUIBIC (UNC-CONICET), Departamento de Química Biológica Ranwel Caputto, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba Haya de la Torre y Medina Allende, Ciudad Universitaria, X5000HUA Cordoba-Argentina TEL: ++54-351-5353850 int. 3443 Web: www.ciquibic.gov.ar E-mail: rafael.oliveira(a)unc.edu.ar <oliveira(a)mail.fcq.unc.edu.ar>

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SALDOS CULTIVO ENERO-FEBRERO 2025
by cultivo＠fcq.unc.edu.ar April 1, 2025

April 1, 2025

Estimados usuarios de cultivo, adjuntamos los saldos correspondientes al bimestre Enero/Febrero 2025. Por favor, les pedimos que envien los datos de facturación para cancelar la deuda y poder reponer material. Muchas gracias. Saludos cordiales Los encargados Laboratorio de Cultivo Celular CIQUIBIC- CONICET Departamento de Química Biológica Facultad de Ciencias Químicas-UNC Laboratorio de Cultivo Celular CIQUIBIC- CONICET Departamento de Química Biológica Facultad de Ciencias Químicas-UNC

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Seminario departamental Jueves 03/04 (14h - EN)
by Mauricio Raul Galiano April 1, 2025

April 1, 2025

Estimados, este *jueves 03/04 a las 14h (EN)* presenta su seminario *Anahi Bignante*, titulado: *Estudio de los mecanismos de modulación del tráfico endo-lisosomal de APP relacionados a la deposición de Aβ y su impacto en la Amiloidogénesis y la Disfunción Endosomal.* *Resumen: *La enfermedad de Alzheimer (EA) es un trastorno neurodegenerativo caracterizado por la deposición cerebral del péptido β-amiloide (Aβ). El Aβ se genera a partir del clivaje secuencial de la proteína precursora del … [View More]amiloide (APP) por BACE1 y luego por la γ-secretasa. El procesamiento de APP está estrechamente ligado a su tráfico intracelular. Nuestro laboratorio se enfoca en el estudio de los factores que modulan la distribución intracelular de APP, con el objetivo de desarrollar estrategias eficientes para regular la amiloidogénesis. Recientemente, hemos encontrado que las formas agregadas de Aβ aumentan la convergencia e interacción de APP y BACE1 en los endosomas de reciclaje (RE) de las neuronas, a través de la activación de una vía de señalización que involucra a la proteína heterotrimérica Go, y en particular, a su subunidad βγ. Esto conduce a un mayor procesamiento de APP por BACE1 y a la acumulación intracelular de Aβ1-42. A partir de estos hallazgos, en el presente proyecto estudiamos cuáles son los mecanismos celulares por los cuales el Aβ agregado favorece el enriquecimiento de APP en la vía endocítica y cuál es el rol de la vía de señalización activada por βγ en este proceso. Mediante técnicas como “pulse-chase” y colocalización cuantitativa, determinamos cómo el Aβ agregado aumenta la tasa de endocitosis y reduce el reciclaje de APP, afectando además su distribución en la vía endo-lisosomal. A través de técnicas como western blot y microscopía de superresolución, observamos que el enriquecimiento de APP en los RE se correlaciona con un incremento en los niveles de la proteína Rab11 y un aumento en el tamaño de tales endosomas. Todos estos efectos fueron prevenidos mediante el pretratamiento con galeína, un inhibidor farmacológico de la señalización mediada por βγ. En conclusión, nuestros resultados sugieren un mecanismo de enriquecimiento endosomal de APP inducido por Aβ agregado, que favorece la amiloidogénesis y la disfunción endosomal, dos eventos tempranos en la EA. Asimismo, nuestros resultados indican que la modulación de la vía de señalización activada por βγ, por ejemplo, mediante galeína, podría constituir una estrategia terapéutica prometedora para frenar la progresión de la enfermedad. Les esperamos. Comisión de Seminarios [image: Seminario (5).png] [View Less]

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Fwd: Proceedings of the National Academy of Sciences Vol. 122, No. 13, April 1, 2025 is now available online
by Marta Hallak April 1, 2025

April 1, 2025

Enviado desde mi iPhone Inicio del mensaje reenviado: > De: PNAS <no-reply(a)pnas.nas.edu> > Fecha: 1 de abril de 2025, 13:13:21 ART > Para: MHALLAK(a)fcq.unc.edu.ar > Asunto: Proceedings of the National Academy of Sciences Vol. 122, No. 13, April 1, 2025 is now available online > Responder a: no-reply(a)pnas.nas.edu > > > > New Issue Available > > APRIL 1, 2025 | VOL.122 | NO.13 > VIEW TABLE OF CONTENTS > > > This Week in PNAS &… [View More]gt; > In This Issue > Science and Culture > > Climate change impacts have potentially big repercussions for kids’ education > Saima Sidik > Commentaries > > Magnetic suppression of quantum tunneling: Insights from Fefferman, Shapiro, and Weinstein > Percy A. Deift > Social control drove ant evolution > Timothy A. Linksvayer > Bacteria on steroids > Natalia Mrnjavac and William F. Martin > Striking the balance: Complexity, simplicity, and credibility in mathematical biology > Cristobal Rodero and Steven A. Niederer > Perspective > > How circuits for habits are formed within the basal ganglia > Sten Grillner > Letters > > Laser imaging of ancient tattoos: New tools illuminate established knowledge > Aaron Deter-Wolf, Benoît Robitaille and Lars Krutak > Reply to Deter-Wolf et al.: Laser-stimulated fluorescence of Chancay tattoos > Thomas G. Kaye, Judyta Bąk, Henry William Marcelo and Michael Pittman > Large language models for identifying social determinants of health > Yu Wang > Reply to Wang: Improving large language model approaches for identifying social determinants of health from clinical notes > Rodney A. Gabriel > Physical Sciences > > Applied Physical Sciences > Rolling vesicles: From confined rotational flows to surface-enabled motion > Paula Magrinya, Pablo Palacios-Alonso, Pablo Llombart, Rafael Delgado-Buscalioni, Alfredo Alexander-Katz, Laura R. Arriaga and Juan L. Aragones > Actuating superparamagnetic nanoparticle monolayers > Edward P. Esposito, Hector Manuel Lopez Rios, Monica Olvera de la Cruz and Heinrich M. Jaeger > Biophysics and Computational Biology > The emergence of eukaryotes as an evolutionary algorithmic phase transition > Enrique M. Muro, Fernando J. Ballesteros, Bartolo Luque and Jordi Bascompte > Chemistry > Adaptive ATP-induced molecular condensation in membranized protocells > Vincent Mukwaya, Xiaolei Yu, Shuo Yang, Stephen Mann and Hongjing Dou > Revealing the roles of the solid–electrolyte interphase in designing stable, fast-charging, low-temperature Li-ion batteries > Lei Tao, Hanrui Zhang, Sameep Rajubhai Shah, Xixian Yang, Jianwei Lai, Yanjun Guo, Joshua A. Russell, Dawei Xia, Jungki Min, Weibo Huang, Chenguang Shi, Zhaohui Liang, Deyang Yu, Sooyeon Hwang, Hui Xiong, Louis A. Madsen, Kejie Zhao, Feifei Shi and Feng Lin > De novo discovery of a molecular glue–like macrocyclic peptide that induces MCL1 homodimerization > Fengwei Li, Mengmeng Zhang, Chao Liu, Jie Cheng, Yawen Yang, Xiangda Peng, Zhifeng Li, Wenfeng Cai, Haipeng Yu, Junjie Wu, Yuyu Guo, Hongkun Geng, Yun Fa, Youming Zhang, Dalei Wu and Yizhen Yin > Intravital imaging of translocated bacteria via fluorogenic labeling of gut microbiota in situ > Xinqi Fan, Yingjun Zhou, Wenjuan Bai, Xue Li, Liyuan Lin, Huibin Lin, Ming Yang, Xiaofei Yu, Jing Wang, Liang Lin and Wei Wang > Computer Sciences > Bridging the human–AI knowledge gap through concept discovery and transfer in AlphaZero > Lisa Schut, Nenad Tomašev, Thomas McGrath, Demis Hassabis, Ulrich Paquet and Been Kim > Earth, Atmospheric, and Planetary Sciences > Climate change amplifies neurotoxic methylmercury threat to Asian fish consumers > Mengjie Wu, Xinda Wu, Alfonso Saiz-Lopez, Paul J. Blanchfield, Hongqiang Ren and Huan Zhong > Using net-zero carbon debt to track climate overshoot responsibility > Setu Pelz, Gaurav Ganti, Robin Lamboll, Luke Grant, Chris Smith, Shonali Pachauri, Joeri Rogelj, Keywan Riahi, Wim Thiery and Matthew J. Gidden > Long-chain alkanes preserved in a Martian mudstone > Caroline Freissinet, Daniel P. Glavin, P. Douglas Archer, Samuel Teinturier, Arnaud Buch, Cyril Szopa, James M. T. Lewis, Amy J. Williams, Rafael Navarro-Gonzalez, Jason P. Dworkin, Heather. B. Franz, Maëva Millan, Jennifer L. Eigenbrode, R. E. Summons, Christopher H. House, Ross H. Williams, Andrew Steele, Ophélie McIntosh, Felipe Gómez, Benito Prats, Charles A. Malespin and Paul R. Mahaffy > Competition response of cloud supersaturation explains diminished Twomey effect for smoky aerosol in the tropical Atlantic > Jeramy L. Dedrick, Christian N. Pelayo, Lynn M. Russell, Dan Lubin, Johannes Mülmenstädt and Mark Miller > Physics > Observation of odd-parity superconductivity in UTe2 > Zixuan Li, Camilla M. Moir, Nathan J. McKee, Eric Lee-Wong, Ryan E. Baumbach, M. Brian Maple and Ying Liu > Statistics > Linear Recursive Feature Machines provably recover low-rank matrices > Adityanarayanan Radhakrishnan, Mikhail Belkin and Dmitriy Drusvyatskiy > Sustainability Science > Climate change amplifies neurotoxic methylmercury threat to Asian fish consumers > Mengjie Wu, Xinda Wu, Alfonso Saiz-Lopez, Paul J. Blanchfield, Hongqiang Ren and Huan Zhong > Using net-zero carbon debt to track climate overshoot responsibility > Setu Pelz, Gaurav Ganti, Robin Lamboll, Luke Grant, Chris Smith, Shonali Pachauri, Joeri Rogelj, Keywan Riahi, Wim Thiery and Matthew J. Gidden > Social Sciences > > Psychological and Cognitive Sciences > Bridging the human–AI knowledge gap through concept discovery and transfer in AlphaZero > Lisa Schut, Nenad Tomašev, Thomas McGrath, Demis Hassabis, Ulrich Paquet and Been Kim > Belief in belief: Even atheists in secular countries show intuitive preferences favoring religious belief > Will M. Gervais, Ryan T. McKay, Jazmin L. Brown-Iannuzzi, Robert M. Ross, Gordon Pennycook, Jonathan Jong and Jonathan A. Lanman > Superficial auditory (dis)fluency biases higher-level social judgment > Robert Walter-Terrill, Joan Danielle K. Ongchoco and Brian J. Scholl > The narrow search effect and how broadening search promotes belief updating > Eugina Leung and Oleg Urminsky > A national megastudy shows that email nudges to elementary school teachers boost student math achievement, particularly when personalized > Angela L. Duckworth, Ahra Ko, Katherine L. Milkman, Joseph S. Kay, Eugen Dimant, Dena M. Gromet, Aden Halpern, Youngwoo Jung, Madeline K. Paxson, Ramon A. Silvera Zumaran, Ron Berman, Ilana Brody, Colin F. Camerer, Elizabeth A. Canning, Hengchen Dai, Marcos Gallo, Hal E. Hershfield, Matthew D. Hilchey, Ariel Kalil, Kathryn M. Kroeper, Amy Lyon, Benjamin S. Manning, Nina Mazar, Michelle Michelini, Susan E. Mayer, Mary C. Murphy, Philip Oreopoulos, Sharon E. Parker, Renante Rondina, Dilip Soman and Christophe Van den Bulte > Most Christian American religious leaders silently believe in climate change, and informing their congregation can help open dialogue > Stylianos Syropoulos and Gregg Sparkman > Biological Sciences > > Biochemistry > Adaptive ATP-induced molecular condensation in membranized protocells > Vincent Mukwaya, Xiaolei Yu, Shuo Yang, Stephen Mann and Hongjing Dou > Cancer-associated SF3B1 mutation K700E causes widespread changes in U2/branchpoint recognition without altering splicing > Andrey Damianov, Chia-Ho Lin, Jian Zhang, James L. Manley and Douglas L. Black > Targeted degradation of α-Synuclein using an evolved botulinum toxin protease > Philipp Sondermann, Christian S. Diercks, Cynthia Rong and Peter G. Schultz > Biophysics and Computational Biology > Jellyfish shape as a mechanical balance > Mengsha Gong, Minakshi Ashok, Ariane Helou and Lea Goentoro > Prediction of phase-separation propensities of disordered proteins from sequence > Sören von Bülow, Giulio Tesei, Fatima Kamal Zaidi, Tanja Mittag and Kresten Lindorff-Larsen > Matrix degradation enhances stress relaxation, regulating cell adhesion and spreading > Badri Narayanan Narasimhan and Stephanie I. Fraley > Allosteric mechanism in the distinctive coupling of Gq and Gs to the parathyroid hormone type 1 receptor > Xuan Zhang, Ji Young Lee, Jonathan Pacheco, Ieva Sutkeviciute, Anju Krishnan Anitha, Heng Liu, Stephanie Singh, Carlos Ventura, Sofya Savransky, Ashok Khatri, Cheng Zhang, Ivet Bahar and Jean-Pierre Vilardaga > Cholesterol-dependent enzyme activity of human TSPO1 > Weihua Qiu, Thi Kim Hoang Trinh, Claudio Catalano, Akul Mehta, Umesh R. Desai, Glen E. Kellogg, Wayne A. Hendrickson and Youzhong Guo > Cell Biology > Lysosomal PIP3 revealed by genetically encoded lipid biosensors > Ayse Z. Sahan, Mingyuan Chen, Qi Su, Qingrong Li, Dong Wang and Jin Zhang > The FBXW7–KMT2 axis in cancer-associated fibroblasts controls tumor growth via an epigenetic-paracrine mechanism > Lu Yin, Jiagui Zhang, Zhipeng Zhu, Xiaojuan Peng, Huiyin Lan, Alex Ayoub, Mingjia Tan, Bo Zhou, Yaohui He, Siyuan Wang, Yan Lu, Wen Liu, Xiufang Xiong, Jing Huang, Yali Dou, Fengbiao Mao and Yi Sun > Ecology > Nanosilica supplementation in tomato increases oviposition on stems and caterpillar mortality in the tomato pinworm > Kokou R. Fiaboe, Fathiya M. Khamis, Xavier Cheseto, Abdullahi A. Yusuf and Baldwyn Torto > Evolution > The emergence of eukaryotes as an evolutionary algorithmic phase transition > Enrique M. Muro, Fernando J. Ballesteros, Bartolo Luque and Jordi Bascompte > Avian cranial kinesis is the result of increased encephalization during the origin of birds > Alec T. Wilken, Kaleb C. Sellers, Ian N. Cost, Julian Davis, Kevin M. Middleton, Lawrence M. Witmer and Casey M. Holliday > Tetrapod species–area relationships across the Cretaceous–Paleogene mass extinction > Roger Adam Close and Bouwe Rutger Reijenga > Genetics > Genomic analysis of 11,555 probands identifies 60 dominant congenital heart disease genes > Michael C. Sierant, Sheng Chih Jin, Kaya Bilguvar, Sarah U. Morton, Weilai Dong, Wei Jiang, Ziyu Lu, Boyang Li, Francesc López-Giráldez, Irina Tikhonova, Xue Zeng, Qiongshi Lu, Jungmin Choi, Junhui Zhang, Carol Nelson-Williams, James R. Knight, Hongyu Zhao, Junyue Cao, Shrikant Mane, Stanley C. Sedore, Peter J. Gruber, Monkol Lek, Elizabeth Goldmuntz, John Deanfield, Alessandro Giardini, Seema Mital, Mark Russell, J. William Gaynor, Eileen King, Michael Wagner, Deepak Srivastava, Yufeng Shen, Daniel Bernstein, George A. Porter, Jane W. Newburger, Jonathan G. Seidman, Amy E. Roberts, Mark Yandell, H. Joseph Yost, Martin Tristani-Firouzi, Richard Kim, Wendy K. Chung, Bruce D. Gelb, Christine E. Seidman, Martina Brueckner and Richard P. Lifton > Immunology and Inflammation > Central TYK2 inhibition identifies TYK2 as a key neuroimmune modulator > Tyler P. Molitor, Genki Hayashi, Mei-Yao Lin, Carissa J. Dunn, Nathan G. Peterson, Robert G. Poston, Michael P. Kurnellas, David A. Traver, Seona Patel, Zeynep Akgungor, Virginia Leonardi, Colizel Lewis, Joshua S. Segales, Dylan S. Bennett, Anh P. Truong, Manjari Dani, Swati Naphade, Jamie K. Wong, Annie E. McDermott, Sarah M. Kovalev, Gillian L. Ciaccio, Saud A. Sadiq, Zhonghua Pei, Stephen Wood and Arash Rassoulpour > An atlas of protein phosphorylation dynamics during interferon signaling > Idoia Busnadiego, Marie Lork, Sonja Fernbach, Samira Schiefer, Nikos Tsolakos and Benjamin G. Hale > Acute TREM2 inhibition depletes MAFB-high microglia and hinders remyelination > Jinchao Hou, Roberta Magliozzi, Yun Chen, Junjie Wu, John Wulf, Gregory Strout, Xiangming Fang and Marco Colonna > Microbiology > Intravital imaging of translocated bacteria via fluorogenic labeling of gut microbiota in situ > Xinqi Fan, Yingjun Zhou, Wenjuan Bai, Xue Li, Liyuan Lin, Huibin Lin, Ming Yang, Xiaofei Yu, Jing Wang, Liang Lin and Wei Wang > Large-scale combination screens reveal small-molecule sensitization of antibiotic-resistant gram-negative ESKAPE pathogens > Megan W. Tse, Meilin Zhu, Benjamin Peters, Efrat Hamami, Julie Chen, Kathleen P. Davis, Samuel Nitz, Juliane Weller, Thulasi Warrier, Diana K. Hunt, Yoelkys Morales, Tomohiko Kawate, Jeffrey L. Gaulin, Jon H. Come, Juan Hernandez-Bird, Wenwen Huo, Isabelle Neisewander, Xiao Yu, Jose A. Aceves-Salvador, Laura L. Kiessling, Deborah T. Hung, Joan Mecsas, Bree B. Aldridge, Ralph R. Isberg and Paul C. Blainey > Cytoplasmic Mg2+ supersedes carbon source preference to dictate Salmonella metabolism > Nick D. Pokorzynski, Katarina A. Jones, Shawn R. Campagna and Eduardo A. Groisman > Modulation of host gene expression by the zinc finger antiviral protein > Daniel Gonçalves-Carneiro, Emily Mastrocola, Xiao Lei and Paul D. Bieniasz > Mechanistic insights into dengue virus inhibition by a clinical trial compound NITD-688 > Yan Wang, Long Sun, Luciana Fernandes, Yu-Hsiu Wang, Jing Zou, Samuel J. Franklin, Yanping Hu, Lee K. Palmer, Jason Yeung, Daniela Barriga, William K. Russell, Stephanie A. Moquin, Pei-Yong Shi, Colin Skepper and Xuping Xie > Neuroscience > Neural basis for individual differences in the attention-enhancing effects of methylphenidate > Peter Manza, Dardo Tomasi, Şükrü Barış Demiral, Ehsan Shokri-Kojori, Christina Lildharrie, Esther Lin, Gene-Jack Wang and Nora D. Volkow > The visuomotor transformations underlying target-directed behavior > Peixiong Zhao, Yuxin Tong, Ivan P. Lazarte, Biswadeep Khan, Guangnan Tian, Kenny K. Y. Chen, Thomas K. C. Lam, Yu Hu and Julie L. Semmelhack > The PVD neuron has male-specific structure and mating function in Caenorhabditis elegans > Yael Iosilevskii, David H. Hall, Menachem Katz and Benjamin Podbilewicz > Explaining human motor coordination via the synergy expansion hypothesis > Federico Tessari, A. Michael West and Neville Hogan > Bayesian inference by visuomotor neurons in the prefrontal cortex > Thomas A. Langlois, Julie A. Charlton and Robbe L. T. Goris > Dopaminergic neurons in the paraventricular hypothalamus extend the food consumption phase > Winda Ariyani, Chiharu Yoshikawa, Haruka Tsuneoka, Izuki Amano, Itaru Imayoshi, Hiroshi Ichinose, Chiho Sumi-Ichinose, Noriyuki Koibuchi, Tadahiro Kitamura and Daisuke Kohno > Expectation-dependent stimulus selectivity in the ventral visual cortical pathway > Tiago S. Altavini, Minggui Chen, Guadalupe Astorga, Yin Yan, Wu Li, Winrich Freiwald and Charles D. Gilbert > Physiology > Control of circadian muscle glucose metabolism through the BMAL1–HIF axis in obesity > Claire A. Chaikin, Abhishek V. Thakkar, Adam W. T. Steffeck, Eric M. Pfrender, Kaitlyn Hung, Pei Zhu, Nathan J. Waldeck, Rino Nozawa, Weimin Song, Christopher R. Futtner, Mattia Quattrocelli, Joseph Bass, Issam Ben-Sahra and Clara B. Peek > Potassium-sensitive loss of muscle force in the setting of reduced inward rectifier K+ current: Implications for Andersen–Tawil syndrome > Nathaniel Elia, Marbella Quiñonez, Fenfen Wu, Ekaterina Mokhonova, Marino DiFranco, Melissa J. Spencer and Stephen C. Cannon > Discovery and functional characterization of a bombesin-type neuropeptide signaling system in an invertebrate > Weiling Huang, Xingxing Zhong, Cleidiane G. Zampronio, Andrew R. Bottrill, Kite G. E. Jones, Ana B. Tinoco, Lijin Guo, Michaela Egertová, Olivier Mirabeau and Maurice R. Elphick > Plant Biology > Structure of ATP synthase from an early photosynthetic bacterium Chloroflexus aurantiacus > Xin Zhang, Jingyi Wu, Zhenzhen Min, Jiamao Wang, Xin Hong, Xinkai Pei, Zihe Rao and Xiaoling Xu > Xylem embolism refilling revealed in stems of a weedy grass > Jared J. Stewart, Brendan S. Allen, Stephanie K. Polutchko, Troy W. Ocheltree and Sean M. Gleason > In situ cavitation bubble manometry reveals a lack of light-activated guard cell turgor modulation in bryophytes > Craig R. Brodersen, Tim J. Brodribb, Uri Hochberg, N. Michele Holbrook, Scott A. M. McAdam, Joseph Zailaa, Brett A. Huggett and Philippe Marmottant > Psychological and Cognitive Sciences > Belief in belief: Even atheists in secular countries show intuitive preferences favoring religious belief > Will M. Gervais, Ryan T. McKay, Jazmin L. Brown-Iannuzzi, Robert M. Ross, Gordon Pennycook, Jonathan Jong and Jonathan A. Lanman > Manipulation of interoceptive signaling biases decision making in rhesus macaques > Michael A. Cardenas, Ryan P. Le, Tess M. Champ, Derek O’Neill, Andrew J. Fuglevand and Katalin M. Gothard > Corrections > > Correction for Ganguli et al., A culture-free biphasic approach for sensitive and rapid detection of pathogens in dried whole-blood matrix > Correction for Magesh et al., Co-zorbs: Motile, multispecies biofilms aid transport of diverse bacterial species > Correction for Quach et al., Deep learning–driven bacterial cytological profiling to determine antimicrobial mechanisms in Mycobacterium tuberculosis > SI Corrections > > Correction to Supporting Information for Struve et al., Systematic changes in circumpolar dust transport to the Subantarctic Pacific Ocean over the last two glacial cycles > Correction to Supporting Information for Schmidt et al., Archaeological adhesives made from Podocarpus document innovative potential in the African Middle Stone Age > Correction to Supporting Information for Stransky et al., Toward a CRISPR-based mouse model of Vhl-deficient clear cell kidney cancer: Initial experience and lessons learned > Correction to Supporting Information for Walters et al., Identification of FSH-regulated and estrous stage–specific transcriptional networks in mouse ovaries > Correction to Supporting Information for Wang et al., Metabolomic insights into pathogenesis and therapeutic potential in adult acute lymphoblastic leukemia > > > > > To update which email alerts you receive, manage your alerts within the My Account area. > > You can also unsubscribe from this alert with one click. > > If you need any further help, please contact us at pnas(a)nas.edu > [View Less]

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FACTURAS PARA CIERRE DE SEDRONAR
by Georgina Vanesa Caceres April 1, 2025

April 1, 2025

Estimados/as: Con motivo del cierre del primer trimestre de SEDRONAR, quienes deban presentar factura, les solicito que me la envíen por este medio. Las compras son las correspondientes éste período (ENERO-FEBRERO-MARZO). Desde ya muchas gracias. Quedo a disposición ante cualquier duda o consulta. Saludos cordiales Ing. Georgina V. Cáceres Centro de Investigación en Química Biológica de Córdoba (CIQUIBIC) Departamento de Química Biológica Ranwel Capputo (DQBRC) Facultad de Ciencias Quí… [View More]

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Fwd: Final Reminder: April 2 - Humanized Models for PK Evaluation of Antibody Therapeutic
by Marta Hallak April 1, 2025

April 1, 2025

Sent from my iPad Begin forwarded message: > From: The Jackson Laboratory <jaxevents(a)jax.org> > Date: April 1, 2025 at 9:15:34 AM GMT-3 > To: mhallak(a)fcq.unc.edu.ar > Subject: Final Reminder: April 2 - Humanized Models for PK Evaluation of Antibody Therapeutic > Reply-To: jaxevents(a)jax.org > > > > UPCOMING EVENT > > > > Upcoming JAX™ Virtual Seminar: > > Next-generation Models for the PK Evaluation of Antibody and Albumin-… [View More]

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URGENTE!!! Llegaron 5 cajas de Merck a nombre de CIQUIBIC - Química Biológica
by Inés Rosa Rodriguez de Priotti April 1, 2025

April 1, 2025

Estimados: Llegaron 5 cajas de Merck y se desconoce el destinatario, viene a nombre de CIQUIBIC - Química Biológica. Envío la factura escaneada y la foto de las cajas que están en Secretaria. El dueño puede pasar a retirarla. Si nosotras no estamos, deje un cartel o mandenos un Whatsapp avisando que las retiró. Saludos cordiales. Inés Rodriguez Secretaria Administrativa Departamento de Química Biológica Ranwel Caputto Facultad de Ciencias Químicas Universidad Nacional de Córdoba Pabellón … [View More]

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